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Mahesh K. Lakshman

@mklakshman.bsky.social
69 followers 83 following 304 posts

Organic chemist, professor, loves (a) classical music, (b) cooking, (c) interesting reads. Oh, and much more...

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Mahesh K. Lakshman @mklakshman.bsky.social · 16h
Dinner last night.
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Mahesh K. Lakshman @mklakshman.bsky.social · 28/09/2026
Chickpea and rice flour pancakes, with tomatoes, onions, green chillies, turmeric powder, cumin and caraway powder, red chili powder, coriander seed powder, and asafoetida powder.
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Mahesh K. Lakshman @mklakshman.bsky.social · 28/09/2026
Uninstructive and low quality spectra and interpretation (how many others?). In the first case, how can an ABq be seen as m? Resonances in the second are low intensity to be useful. Further, how is the anomeric H an m (it is typically a "t" or sometimes a "dd")?
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Mahesh K. Lakshman @mklakshman.bsky.social · 27/09/2026
In the past week, I have read two papers in "reputable" journals where authors "showcase" their chemistry with nucleosides as substrates. The problem is the structures shown are not D-nucleosides. Changing locations of the purine/pyrimidine and the CH2OH produces the enantiomer.
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Mahesh K. Lakshman @mklakshman.bsky.social · 25/09/2026
Dangers of NaH combinations with DMSO, DMF, and DMA. Great info for practitioners. pubs.acs.org/oprdfk/artic...
pubs.acs.org
Explosion Hazards of Sodium Hydride in Dimethyl Sulfoxide, N,N-Dimethylformamide, and N,N-Dimethylacetamide
Abstract. The hazards associated with the thermal decomposition of chemically incompatible sodium hydride solvent matrices are known, with reports from the
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Mahesh K. Lakshman @mklakshman.bsky.social · 21/09/2026
Comment in 2011 by a @J_A_C_S reviewer, "Why would anyone use a diboron reagent which has been carefully assembled through the Na-mediated coupling of chloro(diamino)boranes and converted to its bispinacol derivative to reduce N-oxides..." 175+ cites say otherwise. Peer review!
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Mahesh K. Lakshman @mklakshman.bsky.social · 07/09/2026
Some flowers and pine cones.
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Mahesh K. Lakshman @mklakshman.bsky.social · 07/09/2026
St. Catharine church at Spring Lake.
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Mahesh K. Lakshman @mklakshman.bsky.social · 07/09/2026
Spring Lake.
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Mahesh K. Lakshman @mklakshman.bsky.social · 07/09/2026
Rugosa rose blossoms and fruit!
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Mahesh K. Lakshman @mklakshman.bsky.social · 06/09/2026
Mini farfalle with zucchini, yellow squash, cherry tomatoes, basil, Parmesan and Pecorino Romano.
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Mahesh K. Lakshman @mklakshman.bsky.social · 25/08/2026
Fascinating… www.science.org/content/arti...
science.org
Bearing Sons Can Alter Your Mind
DNA from male fetuses can remain in mothers' brains for a lifetime
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Mahesh K. Lakshman @mklakshman.bsky.social · 13/08/2026
Reactions of hypoxanthine nucleosides with diaryliodonium salts. Atropisomerism observed due to the newly installed N–aryl bond (effect of remote 2'-OTBS group and/or aryl substituent). N-arylation (and not aromatization-driven O-arylation) predominates. doi.org/10.26434/che...
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Mahesh K. Lakshman @mklakshman.bsky.social · 13/08/2026
Wild ponies
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Mahesh K. Lakshman @mklakshman.bsky.social · 30/07/2026
www.nsf.gov/news/nsf-par...
nsf.gov
NSF partners with universities and industry on pilot initiative for four-year Ph.D. programs with real-world research placements
The U.S. National Science Foundation announced a $47 million investment over five years, along with additional financial commitments from nearly three dozen universities and private industry...
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Mahesh K. Lakshman @mklakshman.bsky.social · 20/07/2026
Dal fry time.
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Mahesh K. Lakshman @mklakshman.bsky.social · 25/06/2026
I did not know these stress relief pills were available.
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Mahesh K. Lakshman @mklakshman.bsky.social · 12/06/2026
Now there is an organic compound that shares its name with an adjective applicable to so many at that other venue! 🤣🤣
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Mahesh K. Lakshman @mklakshman.bsky.social · 05/06/2026
A much needed study on farting patterns, a JAMA Network Open study! 🤣🤣🤣
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Mahesh K. Lakshman @mklakshman.bsky.social · 03/06/2026
Spinach sautéed with garlic and chili flakes on a bed of peppered mozzarella on a toasted baguette with mayo/pesto spread.
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Mahesh K. Lakshman @mklakshman.bsky.social · 03/05/2026
Chickpea “sundal” (turmeric, salt, asafoetida, curry leaves, tempered with mustard seeds and red chili in oil, topped with grated fresh coconut, and finished with lime juice).
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Mahesh K. Lakshman @mklakshman.bsky.social · 28/04/2026
@KateBolduan @JohnBerman please note, plants may be poisonous but snakes may be venomous. Poison is consumed, venom is injected. Poisoned and envenomated cannot be interchangeably used.
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Mahesh K. Lakshman @mklakshman.bsky.social · 08/04/2026
At least the cherry tree says it’s spring!
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Mahesh K. Lakshman @mklakshman.bsky.social · 23/03/2026
...and it is out, simple procedure readily implemented.
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Mahesh K. Lakshman @mklakshman.bsky.social · 17/03/2026
Atmospheric pressure catalytic reductions or deuteriations but without use of a compressed gas cylinder, please consider this👇. With deuterations, care must be exercised in product analyses, as there could be unusual outcomes. www.thieme-connect.com/products/ejo...
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Mahesh K. Lakshman @mklakshman.bsky.social · 24/02/2026
Farfallini aglio olio con asparago e crimini.
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Mahesh K. Lakshman @mklakshman.bsky.social · 22/02/2026
One a penny two a penny, hot cross buns, give them to your daughters, give them to your sons. One a penny two a penny hot cross buns.
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Mahesh K. Lakshman @mklakshman.bsky.social · 20/02/2026
Really⁉️⁉️⁉️Does this arise from coworkers' lack of knowledge/understanding, lack of critical analysis, use of software generated multiplicities and J values, lack of oversight by PI, or a combination of these? 10.1021/acs.orglett.1c02040
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Mahesh K. Lakshman @mklakshman.bsky.social · 19/02/2026
What is “pivilic acid” in the ToC? Text priority over beautification?
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Mahesh K. Lakshman @mklakshman.bsky.social · 03/02/2026
Mashed potatoes with garlic, orange, bell pepper, sage and thyme. Topped with pan roasted maitake mushrooms with garlic, sage and thyme (finished with butter). Side of sautéed cherry tomatoes.
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Mahesh K. Lakshman @mklakshman.bsky.social · 28/01/2026
Now to start looking for researchers interested in modifying nucleosides - in directions never before undertaken.
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Mahesh K. Lakshman @mklakshman.bsky.social · 22/01/2026
Pancake time!
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Mahesh K. Lakshman @mklakshman.bsky.social · 20/01/2026
Calling nucleoside chemists. Do you wish to contribute a topical chapter towards a book for a major publisher? If yes, please DM or email.
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Mahesh K. Lakshman @mklakshman.bsky.social · 16/01/2026
Pongal time.
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Mahesh K. Lakshman @mklakshman.bsky.social · 04/01/2026
Kohlrabi with coconut and green chili garnish.
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Mahesh K. Lakshman @mklakshman.bsky.social · 02/01/2026
Ended up with this – twice! I’ll take it.
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Mahesh K. Lakshman @mklakshman.bsky.social · 01/01/2026
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Mahesh K. Lakshman @mklakshman.bsky.social · 31/12/2025
Aloo, gobi, mattar, one of my best versions.
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Mahesh K. Lakshman @mklakshman.bsky.social · 25/12/2025
Stuffed shells and roasted stuffed butternut squash.
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Mahesh K. Lakshman @mklakshman.bsky.social · 28/11/2025
Dinner
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Mahesh K. Lakshman @mklakshman.bsky.social · 17/11/2025
“One-pot” synthesis of an omelette sandwich on sourdough bread.
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Mahesh K. Lakshman @mklakshman.bsky.social · 15/11/2025
From Jacques Offenbach’s Les Contes d’Hoffmann, fun to watch. m.youtube.com/watch?v=mVUp...
m.youtube.com
Patricia JANEČKOVÁ: "Les oiseaux dans la charmille" (Jacques Offenbach - Les contes d' Hoffmann)
YouTube video by Patricia Janečková
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Mahesh K. Lakshman @mklakshman.bsky.social · 13/11/2025
Please record your review experiences with journals at SciRev. In today's mindless garbage-in garbage-out approach to scientific publication, this is important. I just posted about idiotic recent experiences, one with an Editor who possesses a BSc degree. scirev.org
scirev.org
SciRev - Review the scientific review process
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Mahesh K. Lakshman @mklakshman.bsky.social · 08/11/2025
Chickpea chundal or sundal (per cup 14.5 g protein, 12.5 g fiber, and manganese, selenium, potassium, iron, zinc, copper, folate, phosphorus, thiamine, vit B6).
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Mahesh K. Lakshman @mklakshman.bsky.social · 03/11/2025
And voila…makhani dal was conjured up.
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Mahesh K. Lakshman @mklakshman.bsky.social · 02/11/2025
Ran into a famous chemist at a coffee shop, who said they not ready to retire yet, they are doing a lot of great things!
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Mahesh K. Lakshman @mklakshman.bsky.social · 02/11/2025
Congratulations 🇮🇳 women on winning the ICC ODI World Cup.
media.tenor.com
a fireworks display in the night sky with red and white lights
ALT: a fireworks display in the night sky with red and white lights
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Mahesh K. Lakshman @mklakshman.bsky.social · 02/11/2025
Dinner last night (dal rice + onion raita + carrots with black salt, lime juice, cilantro). Dinner tonight big bowl of salad, sperlonga, and cambazola cheese. Tomorrow dal makhani!
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Mahesh K. Lakshman @mklakshman.bsky.social · 29/09/2025
Saffron pancakes with blueberries and peaches.
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Mahesh K. Lakshman @mklakshman.bsky.social · 22/09/2025
A monarch and a mantis. Autumn olives and bayberries.
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