💡 Final PhD paper in NAR: A toolbox for fluorogenic DNA probes aka molecular lightbulbs!
🧬 Flexible in sequence, length, dye
🔬 Single-molecule imaging at μM conc.
🏃♀️➡️ Speeds up DNA-PAINT superres
🌟 No special optics
📄 academic.oup.com/nar/article/...
@kavlioxford.bsky.social @achilleskap.bsky.social
academic.oup.com
Tunable fluorogenic DNA probes drive fast and high-resolution single-molecule fluorescence imaging
Abstract. A main limitation of single-molecule fluorescence (SMF) measurements is the ‘high concentration barrier’, describing the maximum concentration of