iiinova — where your digital self keeps evolving

Michel Reid @michelreid.com · 16/02/2025

Me, trying to keep track of the executive orders, court injunctions, appeals, enforcements, reinstatements, internal policies, positions, communications...

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Michel Reid @michelreid.com · 05/02/2025

I am pleased to report that my 16 y/o is learning unexpectedly practical things in school. I was unpleased to know how practical this was: "Did you know that we are living in a dystopian society right now?" "Well, shit."

Control
• A strong central authority controls politics, the economy, and religion
• Propaganda is used to control citizens
• Citizens are under constant surveillance
• Citizens are forced to conform to uniform expectations
Loss of individuality
• Citizens are deprived of freedom and independent thought
• Citizens are deprived of positive human qualities or basic human rights
• Citizens are forced to conform
Other characteristics
• Citizens do not realize they are being oppressed at first
• The natural world is banished and distrusted
• Societies are engaged in forever wars
• Societies are characterized by extreme social and economic class divides
• Societies are characterized by mass poverty
• Societies are characterized by environmental devastation
• Societies are characterized by anarchy

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Michel Reid @michelreid.com · 05/02/2025

I feel personally attacked by this headline

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Michel Reid @michelreid.com · 12/12/2024

Ladybug wishes you a Happy Holidays!

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Michel Reid @michelreid.com · 07/12/2024

I take no credit for this. Blame my kids...

Chuck E. Cheese > Charlie Entertainment Cheese > Charles De Brie

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Michel Reid @michelreid.com · 04/12/2024

Who did it better? My #TripodCat Ladybug or... Jabba the Hutt?

Grey cat laying back with eyes half open

Greenish Hutt gangster of Tattoine, with eyes half open

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Michel Reid @michelreid.com · 30/11/2024

Sorry y'all, had to share because it got me. 😏

In 1920, 8 year old Samuel Reshevsky played chess with several chess masters at once. He lost every single game.

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Michel Reid @michelreid.com · 27/11/2024

Show me a picture on your phone that has your energy that isn't a selfie.

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Michel Reid @michelreid.com · 25/11/2024

"I still have more legs than you, hoomin!" This is our #tripod #cat. His name is Ladybug, and he amazes (and/or cracks me up) me everyday. As we are the only two boys in the house, he's my buddy. The other two cats (and other people) are girls, and so we stick together. 😽

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Michel Reid @michelreid.com · 24/11/2024

So many posts and articles talking about how "left-wing" #Bluesky is and how "right-wing" Xitter is, but that's not the defining attribute. It really comes down tolerated behavior. Here, just be cool. Have your opinion, and be cool about it. Will be really cool to see this be a pivotal movement!

White text on a black background, stating "Culture is the byproduct of consistent behavior"

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Michel Reid @michelreid.com · 24/11/2024

This is what I found. Yes, the higher trims go from 77kWh to 84kWh. This is encouraging!

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Michel Reid @michelreid.com · 22/11/2024

Tell me again why being #woke is supposed to be a bad thing? Time to recapture the term.

A billboard on a brick building, with the word "woke" in very large text, presented as if in an dictionary, with the definition "aware, especially of social problems such as racism and inequality."

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Michel Reid @michelreid.com · 20/11/2024

#RepresentationMatters As recently as 2023... There continues to be massive representation gaps in what is portrayed to children: www.scientificamerican.com/article/are-... Does this matter? The short answer, yes. Why does this matter? Because this is what we mean when we say "systemic" racism.

Charts from Scientific American, portraying the under-representation (compared to census representation in the United States) of non-white people in mainstream children's books.

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Michel Reid @michelreid.com · 20/11/2024

Fact #5 ➡️ It is for both girls AND BOYS. www.cdc.gov/hpv/media/pd... www.nationwidechildrens.org/family-resou...

So why should boys, who aren’t at risk of cervical cancer, care about this vaccine? HPV is a very common sexually transmitted infection affecting 40% of adults aged 15-59. While many types of HPV do not cause any health problems, there are several types that are directly linked to the development of different cancers: cervical cancer in women, but penile cancer in men, anal cancer in both men and women as well as throat, tongue and tonsil cancers. Many of these cancers develop silently and can be discovered years or even decades after exposure to HPV. They can be very aggressive and even fatal. The vaccine also protects against precancerous lesions and genital warts.

Four out of every 10 cases of HPV related cancer are in males. Currently there is no screening for these cancers in men, and no treatment for HPV once the virus is contracted. This makes HPV prevention with the vaccine even more essential.

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Michel Reid @michelreid.com · 19/11/2024

I can't stand disengenuous nonsense

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Michel Reid @michelreid.com · 18/11/2024

"The Health Research Authority (HRA) and the Medicines and Healthcare products Regulatory Agency (MHRA) are committed to enabling the highest quality health and social care research which can benefit the whole UK population." www.hra.nhs.uk/about-us/new...

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Michel Reid @michelreid.com · 18/11/2024

#ICYMI Did you know that GSK published a paper about their own experience in representation in clinical trials? Clinical Trials: Journal of the Society for Clinical Trials Demographic diversity of US-based participants in GSK-sponsored interventional clinical trials doi.org/10.1177/1740...

Background:
Demographic diversity among clinical trials is required for representing the real-world populations intended for treatment and disease prevention. Moreover, genetic and environmental differences between ethnic and racial groups necessitate appropriately powered trials for relevant subgroups. We investigate the racial and ethnic demographic diversity of US-based participants in GSK-sponsored interventional trials. We also assess the evaluation of demographic diversity against US Census and epidemiologic data.

Methods:
GSK-sponsored interventional phase I–IV clinical trials conducted from 2002 to 2019 across three areas were analyzed: pharmaceutical (includes therapeutic medicines except for vaccines and human immunodeficiency virus (HIV)), vaccine (includes prophylactic and therapeutic vaccines), and ViiV (includes HIV therapies). A total of 1005 global trials encompassing 460,707 global participants were identified, of which 495 had US-based sites with a total of 108,261 (23.5% of global) US participants (pharmaceutical, n = 357 trials; vaccine, n = 45 trials; and ViiV, n = 93 trials). We evaluated how GSK US-based trial recruitment compares with US Census (in line with previously published studies from other groups) and with epidemiologic data.

Results:
GSK participant data for race and ethnicity combined across areas were generally similar to US Census levels (e.g. GSK versus census: White, 76.5% versus 76.3%; Black or African American, 15.1% versus 13.4%; Asian, 1.8% versus 5.9%; Hispanic or Latino, 14.0% versus 18.5%; Non-Hispanic White, 63.5% versus 60.1%). However, this was not the case for the individual pharmaceutical, vaccine, and ViiV data sets; least represented groups were Asian individuals for pharmaceutical and ViiV trials and American Indian or Alaskan Native individuals for vaccine trials (6.2%, 11.8%, and 11.1% of trials met/exceeded census level representation, respectively). The percentage of trials reaching/exceeding census levels also varied per trial phase for race and ethnicity. Furthermore, disparities in the percentage of trials reaching/exceeding census levels versus epidemiology-based prevalence levels have revealed opportunities to improve industry success metrics; in HIV trials, the proportion of Black or African American individuals (35.1%) exceeded census (13.4%) but not epidemiologic levels (55.3%).
Conclusion:
Further work is required to achieve demographic diversity across clinical trials. We conclude that US Census data are an inappropriate universal benchmark. A shift to epidemiology benchmarking will enable the consideration of global participants into US analyses for highly intrinsic (i.e. influenced by ancestry) diseases and more firm requirements for US-based participants into US analyses for extrinsic (i.e. influenced by location or culture) diseases. Benchmarking in line with epidemiologic data will allow us to set better trial enrollment goals, with the aim of conducting more demographically balanced, diverse, and representative clinical trials and enabling a better understanding of drug safety and efficacy per demographic group.

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Michel Reid @michelreid.com · 18/11/2024

#ICYMI Did you know that Pfizer published a paper about their own experience in representation in clinical trials? Contemporary Clinical Trials Volume 106, July 2021, 106421 Demographic diversity of participants in Pfizer sponsored clinical trials in the United States doi.org/10.1016/j.cc...

Title block of manuscript "Demographic diversity of participants in Pfizer sponsored clinical trials in the United States"

Manuscript Abstract. Highlights
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Limited data have previously been reported regarding clinical trial diversity from drug sponsors.
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Race, ethnicity, gender, and age data for participants in Pfizer US trials initiated between 2011 and 2020 are summarized.
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The results establish a baseline of clinical trial diversity to measure improvement over time.
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Future analyses will allow exploration of factors leading to and arising from disparities in clinical trial participation.

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Michel Reid @michelreid.com · 17/11/2024

The cabinet is representing the people who voted for him, not the people he's supposed to be governing...

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Michel Reid @michelreid.com · 16/11/2024

Why Equity Needs to Become Obligatory "The vast majority of research used to understand risk factors and treatments remains rooted in populations with predominantly European ancestry" www.insideprecisionmedicine.com/topics/patie... #ClinicalTrialDiversity #InclusiveResearch #HealthEquity

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Michel Reid @michelreid.com · 16/11/2024

Always put your own oxygen mask on first so that you can still be around to help others without adding to the problem.

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Michel Reid @michelreid.com · 15/11/2024

"We cannot choose our external circumstances, but we can always choose how we respond to them." -Epictetus ...or, sometimes our circumstances are chosen in spite of us. Regardless, we can choose how we respond.

A diverse group of mostly black and brown people gathered in close proximity, seemingly at an outdoor event. Above them, there's a large structure with a quote that reads, 'We cannot choose our external circumstances, but we can always choose how we respond to them.' The quote is attributed to Epictetus. The crowd appears to be in various states of emotion, with some looking concerned, others in deep thought. The background is filled with trees and a clear sky, suggesting the event is taking place in a park or open area.

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Michel Reid @michelreid.com · 15/08/2023

Raise your hand if you have been burned by #MicrosoftTeams #UX design putting the "Stop Sharing" button next to the "Leave Meeting" button. ✋🏽🙄

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Michel Reid @michelreid.com · 23/09/2022

Happy Birthday to me, from Reids 1.0 #IYKYK #ifyouknowyouknow

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Michel Reid @michelreid.com · 20/09/2022

It's easy to do, check your state requirements here: #vote

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Michel Reid @michelreid.com · 29/08/2022

Dear @US_FDA, you have a typo on your webpage about Clinical Trial Diversity

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Michel Reid @michelreid.com · 05/04/2022

National Minority Health Month was established in 1915. More than 100 years later, check out @MinorityHealth to acknowledge health disparities that continue to affect racial & ethnic minority communities.

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Michel Reid @michelreid.com · 01/03/2022

Let’s debunk misinformation & encourage our communities to get fully vaccinated this April, during National Minority Health Month (#NMHM2022). #BoostYourCommunity with facts on vaccines and boosters. Learn more about this year's theme from @MinorityHealth:

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