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Michal Santocki

@michalsantocki.bsky.social
36 followers 84 following 14 posts

Postdoctoral Researcher at Frič lab, ICRC, St. Anne's University Hospital Brno | Investigating long-term effects of sepsis | Organoids enthusiast | Myeloid cells geek | #immunology #sepsis #innateimmunity #intravitalmicroscopy #organoids 👨🏻‍🔬🔬🩸

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Reposted by Michal Santocki
Fric_Immuno_Lab @friclab.bsky.social · 10/10/2025
FricLab at @csac-cz.bsky.social 2025 conference Jan @friclab.bsky.social presented pre @beatsepsis.bsky.social data @michalsantocki.bsky.social - BMniche remodelling in sepsis, @zuzanatomasik -EoE project @pap_joanna postCOV neutrophils
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Reposted by Michal Santocki
WHO @who.int · 13/09/2025
It’s World #Sepsis Day Sepsis kills 11 million people each year. Symptoms incl.: 🔸Fever or shivering 🔸Confusion 🔸Shortness of breath 🔸Rash that does not fade when pressed 🔸Extreme discomfort 🔸Sweaty skin Seek medical care as soon as possible when an infection is not getting better.
What is sepsis?
Sepsis arises when a person has an infection, and the body's reaction to it injures tissues and organs
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Reposted by Michal Santocki
Blood Journals Portfolio @bloodjournals.hematology.org · 05/05/2025
In vivo physiological removal of NETs induces second-wave traps, altering the severity of subsequent infection, depending on its timing. buff.ly/9VmItHw #hemesky #phagocytesgranulocytesandmyelopoiesis
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Michal Santocki @michalsantocki.bsky.social · 01/05/2025
I’m thrilled to share that the article based on the findings from my doctoral thesis has been published in the Blood journal! @bloodportfolio.bsky.social Our study reveals the unexpected longevity and self-renewal of NETs within liver blood vessels during sepsis!🕸️🔬 tinyurl.com/mxph8mrr #sepsis #NETs
tinyurl.com
NETs persisting in vasculature undergo self-renewal with consequences for subsequent infection: a mouse model study
Key PointsNET protein components adhere to vascular endothelium for 5 to 8 months, whereas DNA is detached within days but circulates for up to a year.In v
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Michal Santocki @michalsantocki.bsky.social · 21/02/2025
Excited to share our new paper🚨📝 We explored SLPI's role in neutrophil migration in psoriasis! Full paper: link.springer.com/article/10.1... Big thanks to co-authors! 🙌 #neutrophils #inflammation #psoriasis #SLPI
link.springer.com
SLPI controls neutrophil migration abilities and impacts neutrophil skin infiltration in experimental psoriasis - Cellular and Molecular Life Sciences
Skin infiltration by neutrophils is a hallmark of the chronic inflammatory skin disease psoriasis, yet the mechanisms underlying neutrophil recruitment and positioning in chronically inflamed skin rem...
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