iiinova — where your digital self keeps evolving

Mark Groeneveld @mgroeneveld.bsky.social · 29/08/2026

Thanks! She got back to me and cleared up the confusion about the Clinic vs Personalized Psychiatry.

Mark Groeneveld @mgroeneveld.bsky.social · 28/08/2026

Do you know if the clinic is open? I link to them in my manual and want to verify that I have their details correct. I haven't been able to contact Dr. Bekhrad. I also called the number on the clinic's website and the person who answered said they weren't associated with the clinic.

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Mark Groeneveld @mgroeneveld.bsky.social · 14/08/2026

I made a list of informal hypotheses about why MDMA facilitates MR/prior-updating in Appendix D of osf.io/preprints/psyarxiv/aps5g. I’d be curious to hear what you think.

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Mark Groeneveld @mgroeneveld.bsky.social · 14/08/2026

I’ve also spent a lot of time trying to closely observe the microphenomenology of this process and figure out why MDMA facilitates reconsolidation. It’s an important question but I can’t say that I’ve had any important or novel conclusions.

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Mark Groeneveld @mgroeneveld.bsky.social · 14/08/2026

I started out with a therapist who showed me how it works, then transitioned to solo. I had the exact same durably therapeutic process with and without. I just trigger myself, stay present with the feelings, and the MDMA reconsolidates the underlying mental model.

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Mark Groeneveld @mgroeneveld.bsky.social · 14/08/2026

I think the fact that many people (including myself) on /r/mdmatherapy report successful solo MDMA therapy also suggests that therapy is not necessary. The reports often mention classic signs of trauma processing, so I don’t think they’re just incorrect.

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Mark Groeneveld @mgroeneveld.bsky.social · 13/06/2026

I hope it can be of use to more people but have only tested it on my computer. If anyone is interested in testing it I’m happy to help out and make sure it works for you too!

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Mark Groeneveld @mgroeneveld.bsky.social · 13/06/2026

I wrote a script for latex papers that uses the Claude Code command line interface to double-check whether your citations actually support the claims they're attached to, by reading the cited PDF(s) and comparing them to your claim.

github.com

GitHub - groeneveld/latex_claim_verifier: Verifies that each claim in a latex paper is supported by its citations.

Verifies that each claim in a latex paper is supported by its citations. - groeneveld/latex_claim_verifier

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Mark Groeneveld @mgroeneveld.bsky.social · 30/05/2026

I've been assuming that Active Protection Systems and laser weapons will put a big dent in the effectiveness of drones.

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Mark Groeneveld @mgroeneveld.bsky.social · 21/05/2026

Do you know why they require so much lab work? I was under the impression that physical contraindications for psilocybin are minimal.

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Mark Groeneveld @mgroeneveld.bsky.social · 27/04/2026

It seemed to be non-directive therapy like the MAPS trials, but without integration sessions.

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Mark Groeneveld @mgroeneveld.bsky.social · 27/04/2026

The session frequency was intense and they wished they had regular integration sessions.

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Mark Groeneveld @mgroeneveld.bsky.social · 27/04/2026

They discussed their processing with their therapist during each session and in an optional patient-requested integration session after the treatment ended. Some integration from the previous dosing session also happened at the start of subsequent dosing sessions before dosing.

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Mark Groeneveld @mgroeneveld.bsky.social · 27/04/2026

I'm talking with a patient from the Otsuka/Transcend methylone phase-II trial. They said there it essentially included therapy. The drug was presented as something that would help them process emotions/memories, like MDMA does. They planned to address certain emotions/memories before each session.

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Mark Groeneveld @mgroeneveld.bsky.social · 25/04/2026

I don't love the title. They explicitly say some types of future AI could be conscious.

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Mark Groeneveld @mgroeneveld.bsky.social · 13/04/2026

The unblinding point makes sense to me. Does that collapse the two indirectness points into one point though? Is there another proposed mechanism of action for not-representativeness affecting how the results apply to the general population that would apply even though MAPS showed minimal difference

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Mark Groeneveld @mgroeneveld.bsky.social · 10/04/2026

You mention that the high prior use of MDMA influenced your grade assessment. I’m curious if you took into consideration the MAPS report (www.fda.gov/media/179062...; page 81) that mentions that prior use of MDMA barely affected their phase III results.

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Mark Groeneveld @mgroeneveld.bsky.social · 10/04/2026

The intervention doses for the two Mitchell studies might not be right on www.metapsy.org/sypres/mdma-.... The studies used roughly 120+60 IIRC, but metapsy reports 120.

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Mark Groeneveld @mgroeneveld.bsky.social · 20/03/2026

Additionally, the group that had two 25mg sessions didn’t show any advantage over one 25mg session, so it looks like one psilocybin session adds durable benefit but another session doesn’t add anything more.

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Mark Groeneveld @mgroeneveld.bsky.social · 20/03/2026

This advantage seems to disappear at the endpoint after session 2 because the other groups also take 25mg psilocybin and catch up to the group that had 25mg in session 1.

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Mark Groeneveld @mgroeneveld.bsky.social · 20/03/2026

I wasn’t talking about the primary endpoint. If you look at Figure 2 you can see that 25mg psilocybin appears to have a large, statistically significant advantage over placebo after session 1.

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Mark Groeneveld @mgroeneveld.bsky.social · 19/03/2026

My reading is that psilocybin did outperform placebo, but more than one psilocybin dose didn't add anything. So after the first session, the psilocybin has an advantage, then everything comes out equal at the end because the other groups also take psilocybin and catch up.

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Mark Groeneveld @mgroeneveld.bsky.social · 08/03/2026

You can say the same thing about humans. Given that no one really understands what consciousness is, there is no extraordinary evidence that humans are conscious, and there is no reason that humans require consciousness to have their neural networks function and output speech.

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Mark Groeneveld @mgroeneveld.bsky.social · 07/03/2026

I feel skeptical about any under/over diagnosis discussion for a construct that both hitop and doi.org/10.31234/osf... suggest is not a distinct entity, but rather a hodgepodge collection of symptoms. How can under/over diagnosis have any rigorous meaning in such a case.

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Mark Groeneveld @mgroeneveld.bsky.social · 22/02/2026

The only information they have is the paragraph talking about blinding assessment in the publication.

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Mark Groeneveld @mgroeneveld.bsky.social · 21/02/2026

It's not in the supplemental data and I didn't find any reference on the web to that being a standard questionnaire.

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Mark Groeneveld @mgroeneveld.bsky.social · 21/02/2026

For reference, the Methylone study participants correctly guessed they got methalone (70%) or placebo (53%). That’s much less than MAPP2: MDMA (93%); placebo (75%). But that's not corrected for the differences in measurement.

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Mark Groeneveld @mgroeneveld.bsky.social · 21/02/2026

The “got placebo” bin in the methylone study was also wider than their “got methylone” bin. It seems weird to have a lopsided scale. MAPP2 was symmetric.

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Mark Groeneveld @mgroeneveld.bsky.social · 21/02/2026

I noticed that too and dug in more: Blinding might not be comparable: the methylone study had a wider middle bin of “unsure” responses than MAPP2. The methylone study also didn’t report the details of the middle bin; responses could have been lopsided.

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Mark Groeneveld @mgroeneveld.bsky.social · 21/02/2026

Measuring therapeutic effect is also tricky because of the “it feels worse before it gets better” destabilization phase in therapy. Destabilization predicts better long-term outcomes (10.1080/10503307.2019.1633484). Participants's stories might shed light on how this influenced the results.

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Mark Groeneveld @mgroeneveld.bsky.social · 21/02/2026

I’d love to know what was happening from the participants’ perspective. I presume they are doing memory reconsolidation since the trial reports persistent improvements. Did they have psychotherapeutic intent? MR not infrequently happens on MDMA when people aren’t using it for escapism.

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Mark Groeneveld @mgroeneveld.bsky.social · 21/02/2026

Interesting: The change in CAPS-5 was similar to the MDMA results from MAPP2 even though the methylone trial didn’t include therapy. SDS improvements favored methylone.

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Mark Groeneveld @mgroeneveld.bsky.social · 18/02/2026

I wasn't sure what you were presenting it as an example of. :P

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Mark Groeneveld @mgroeneveld.bsky.social · 17/02/2026

The depression and anxiety diagnoses falsely communicated to me that my issues didn't have a known etiology and cure.

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Mark Groeneveld @mgroeneveld.bsky.social · 17/02/2026

I also found the diagnoses given to me as an adult (depression and anxiety) unacceptable myths once I realized my symptoms were simply maladaptive implicit memories learned during the period of abuse that I could permanently unlearn with memory reconsolidation.

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Mark Groeneveld @mgroeneveld.bsky.social · 17/02/2026

I think the illness myth given to me was severely harmful and untrue. My parents were emotionally abusing me. A psychiatrist diagnosed me with ADHD, and my family bought into that as a way to avoid the real issue. ADHD was an acceptable myth to them; their abusive behavior was not.

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Mark Groeneveld @mgroeneveld.bsky.social · 17/02/2026

Quite evocative! Do you feel that that metaphor was a helpful or unhelpful myth?

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Mark Groeneveld @mgroeneveld.bsky.social · 16/02/2026

Yea...sigh This just reminded me to actually read Benish. Ever since I read Luck's description of the illness myth I've been thinking that it might describe a large fraction of current practice and research across the different fields of mental health.

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Mark Groeneveld @mgroeneveld.bsky.social · 16/02/2026

I want PVT to go away so bad. Even the academic literature on tonic immobility, freeze, and fight-or-flight is filled with the nonsense.

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Mark Groeneveld @mgroeneveld.bsky.social · 16/02/2026

This is by far the best explanation of why polyvagal theory is popular that I've come across: alyssaluck.com/polyvagal-th...

alyssaluck.com

Polyvagal Theory: A Critical Appraisal

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Mark Groeneveld @mgroeneveld.bsky.social · 14/02/2026

It reminds me how when people become practiced enough at meditating, it's easy to notice how perceptions all pop into existence and then disappear at roughly brain wave frequencies.

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Mark Groeneveld @mgroeneveld.bsky.social · 12/02/2026

I noticed when they described fear extinction in the paper it seemed like they were actually describing memory reconsolidation since they called it unlearning. I've noticed this pattern in a lot of places; people seem to call both phenomena fear extinction.

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Mark Groeneveld @mgroeneveld.bsky.social · 11/02/2026

The LLM models they looked at are all old crappy ones compared to the current batch. AI moves so fast that by the time a paper is out, the results are out of date.

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Mark Groeneveld @mgroeneveld.bsky.social · 14/01/2026

I agree that pain, or any of the typical qualia reported by humans, is unlikely to be present inside any particular boundary (like a thumb) not associated with human/animal cognition, but some sort of more basic or foreign experience might exist.

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Mark Groeneveld @mgroeneveld.bsky.social · 14/01/2026

I don't think it's a Russellian teapot. A significant portion of the proposed solutions to the Hard Problem posit that everything has/is some form of experience. The assumption that those solutions are unlikely is our culture's semi-arbitrary prior.

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Mark Groeneveld @mgroeneveld.bsky.social · 14/01/2026

I'm confused why it defines consciousness as phenomenal experience, but then effectively treats consciousness as what might be called "reported consciousness," which is different than phenomenal experience. The heart-rate regulator could have a simple phenomenal experience that isn't reportable.

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Mark Groeneveld @mgroeneveld.bsky.social · 16/12/2025

Those issues are just a quirk of the method they use to parse text called tokenization. It's not a fair representative of their capabilities.

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Mark Groeneveld @mgroeneveld.bsky.social · 08/12/2025

My first project will be identifying the causal factors people ascribe to MDMA-therapy-induced, severe destabilization (psychosis, mania, or unworkable panic or dissociation). Identifying these factors will help to better communicate and assess risk factors for people considering MDMA therapy.

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