Neurodegenerative disorders such as Alzheimer’s (AD) and Parkinson’s (PD) have traditionally been examined from the perspectives of neurons or microglia, resulting in constrained therapeutic achieveme...

Background Preclinical and human brain postmortem studies indicate that progressive supranuclear palsy (PSP) is associated with increased expression of the retrotransposon Long Interspersed Nuclear ...

Purpose of reviewFacioscapulohumeral muscular dystrophy is one of the most frequent myopathies. Its clinical presentation and genetic background are...

Provided herein are novel compounds as TREM2 agonists, pharmaceutical compositions, use of such compounds in treating Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Nasu-Hakola disease, and stroke, and processes for preparing such compounds.

Background Lower urinary tract symptoms (LUTS) are a common and burdensome part of Parkinson’s disease (PD). Conventional treatments are inconsistently effective, making minimally invasive options lik...

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Roche's drug lowered mutant HTT, lowered NfL, but produced no clinical benefit. There are three explanations for why. The one with the best biological case is the one nobody is funding.

SEOT provides complementary, independent, and often stronger predictive value than tau load for brain metabolism, particularly for network-level dysfunction. SEOT may improve diagnostic characterisati...

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Healis Therapeutics opens IND, enabling first U.S. trials for Depression, PTSD, and neuropsychiatric disorders...

This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.

The tests aren’t a guarantee that someone will develop dementia, but that hasn’t stopped people from getting them.

Background There is a lack of treatments for non-motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and...

On AI, human biology, and what it will actually take to discover transformative new medicines

Aspen Neuroscience, Inc., a clinical-stage regenerative medicine biotechnology company developing personalized, autologous cell therapies, today announced that sasineprocel (ANPD001), its lead investi...

Mitochondrial dysfunction features prominently in tauopathies. The mechanistic link between tau and mitochondria remains uncertain. Li et al. show that tau enters mitochondria and interacts with compl...

Cough Hypersensitivity Syndrome (CHS) stands as the definitive pathological phenotype of refractory chronic cough, characterized by a sensory nervous system ...

Background Cough is a common and burdensome symptom in patients with progressive pulmonary fibrosis (PPF), yet existing evidence remains fragmented. This systematic review provides a synthesis of avai...

Background Cough is a common and burdensome symptom in patients with progressive pulmonary fibrosis (PPF), yet existing evidence remains fragmented. This systematic review provides a synthesis of avai...

npj Health Systems - Beyond fingerprint and voice print: cough sequence sound for identity verification

Objective To characterize validation approaches used in ambulatory cough monitoring systems and identify methodological variability that may limit clinical and research applications. Study Design Scop...

Background Cough-specific visual analogue scale (VAS) is widely used to assess cough severity and frequency; however, clinically meaningful thresholds for treatment response in chronic cough (CC) rema...

AusculPatch, which records heart, breathing and pulse signals, is set for AI-assisted deterioration detection testing.

Our results show that we derived the following patient-anchored criteria for cough control incorporating objective and subjective outcomes: 24-hour CF of ≤ 10 coughs/h, CS-VAS of ≤ 30 mm, and LCQ scor...