Reposted by Maria N. de Menezes
It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social to preview a great upcoming article in @cp-immunity.bsky.social by @kamphorstlab.bsky.social showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells.
www.cell.com/immunity/abs...
cell.com
The high (I)COSt of costimulation for exhausted T cells
ICOS agonists are being investigated for cancer immunotherapy based on the idea that
they will reinvigorate exhausted CD8+ T cell anti-cancer immunity. Humblin et al.
unexpectedly find the opposite—th...