🧵 Thread on our new @natcomms.nature.com paper: TLDR -- ADP-ribosylation inhibits viral replication and represents a previously under-appreciated arm of innate immunity during flu infection. Read along for the details…. (1/11) www.nature.com/articles/s41...
nature.com
Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection - Nature Communications
Influenza A virus infection causes a dramatic upregulation of ADP-ribosylation that as part of the cellular antiviral response, a process that is counteracted by the viral NS1 protein.
