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Mebratu Bitew

@mebratubitew.bsky.social
36 followers 61 following 15 posts

DVM, PhD| Interested in Host-Parasite interaction on Toxoplasma gondii

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Mebratu Bitew @mebratubitew.bsky.social · 17/12/2025
Thrilled to share some great news—my new paper is published in @natcomms.nature.com and out today! We conducted a genome-wide CRISPR screen in Toxoplasma gondii and identified GRA38, a dense granule protein, as a key regulator of lipid homeostasis www.nature.com/articles/s41...
nature.com
A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions - Nature Communications
Here, using a genome-wide CRISPR screen, Bitew et al. identify GRA38, a phosphatidic acid phosphatase, as a key factor in Toxoplasma gondii adaptation to lipid-rich conditions via keeping lipid balanc...
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Mebratu Bitew @mebratubitew.bsky.social · 21/04/2025
Excited to share our new preprint: We uncover how Toxoplasma senses host lipid levels and adapts metabolically to survive in different nutrient environments. www.researchsquare.com/article/rs-6...
researchsquare.com
A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions
Intracellular parasites like Toxoplasma gondii scavenge host nutrients, particularly lipids, to support their growth and survival. Although Toxoplasma is known to adjust its metabolism based on nutrie...
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