iiinova — where your digital self keeps evolving

mdj-journal.bsky.social @mdj-journal.bsky.social · 29/09/2026

Evidence-based review analyses and clinical practice guidelines are complementary, not competing, tools. The MDS EBM and EAN/MDS-ES Guideline committees explain how using such tools together leads to more informed patient-centered decisions. loom.ly/sduK2Xg

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mdj-journal.bsky.social @mdj-journal.bsky.social · 16/09/2026

An intriguing 15-year follow-up of patients with isolated generalized dystonia treated with bilateral GPi-DBS. loom.ly/tpE0xPY

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mdj-journal.bsky.social @mdj-journal.bsky.social · 10/09/2026

Sleep architecture and circadian rhythms are profoundly altered in PD, but can we actually decode them from the basal ganglia?https://loom.ly/XbsG2To

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mdj-journal.bsky.social @mdj-journal.bsky.social · 08/09/2026

An excellent viewpoint on the long-duration response (LDR) to levodopa—an intriguing yet underrecognized and under-investigated phenomenon in Parkinson’s disease. loom.ly/xpoI2bs

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mdj-journal.bsky.social @mdj-journal.bsky.social · 26/08/2026

An important study by Leocadi and colleagues provides the first longitudinal evidence of early cortico-striatal and cerebellar functional network alterations in adult Huntington’s disease gene-expanded (HDGE) individuals—changes detectable decades before clinical motor onset. loom.ly/PSn6o24

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mdj-journal.bsky.social @mdj-journal.bsky.social · 20/08/2026

A timely position paper by Kulisevsky et al. provides an excellent framework for understanding, assessing, and managing apathy in PD and DLB—and highlights how much remains to be done therapeutically. loom.ly/QDeWHwI

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mdj-journal.bsky.social @mdj-journal.bsky.social · 13/08/2026

Are there really meaningful differences between α-Syn-SAA–negative and –positive Parkinson’s disease? Brooker and colleagues report that, apart from greater hyposmia in the SAA+ group and more subcortical atrophy in the SAA− group, the phenotypes appear remarkably similar. loom.ly/qBHAVTM

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mdj-journal.bsky.social @mdj-journal.bsky.social · 10/08/2026

Does cannabis-based oil improve pain in Parkinson’s disease? A phase II, randomized, placebo-controlled trial by Kubota et al. found no significant improvement in pain measured by the PD-Pain Classification System with a CBD/THC formulation (CBD 96 mg/mL; THC 2.1 mg/mL). loom.ly/VYh5T5M

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mdj-journal.bsky.social @mdj-journal.bsky.social · 29/07/2026

Repeat MRI-guided focused ultrasound thalamotomy restored meaningful tremor control in patients with ET and tremor-predominant PD. Although repeat treatment was associated with more side effects, 85% of patients would choose retreatment again. loom.ly/ngrFPw0

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mdj-journal.bsky.social @mdj-journal.bsky.social · 21/07/2026

This increase reflects the dedication of our editorial teams and contributors worldwide. Congratulations! Your discoveries and commitment are shaping the future of our field. loom.ly/1Od7Fjg

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mdj-journal.bsky.social @mdj-journal.bsky.social · 20/07/2026

MDS prodromal MSA criteria identified nearly all future MSA cases (92–100% sensitivity), but specificity was modest. Patients who phenoconverted to MSA were younger and had more severe urinary dysfunction and greater orthostatic heart rate responses. loom.ly/sjAsOec

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mdj-journal.bsky.social @mdj-journal.bsky.social · 07/07/2026

In this interesting study, Puisieux and colleagues report significantly higher plasma homocysteine levels in both symptomatic and premanifest Huntington's disease compared with controls. loom.ly/rEgKvAE

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mdj-journal.bsky.social @mdj-journal.bsky.social · 02/07/2026

A must-read article by Corcos and colleagues for anyone caring for people with Parkinson's disease. The authors make a compelling case that exercise and lifestyle modification aren't just complementary therapies, they're essential parts of Parkinson's disease management. loom.ly/VInVkRM

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mdj-journal.bsky.social @mdj-journal.bsky.social · 29/06/2026

PD causes frequency-specific, state-dependent reorganization of the cortical hierarchy. Functional gradient biomarkers derived from high-density EEG accurately predict motor severity and highlight optimal cortical sensing sites for next-generation cortical-guided adaptive DBS loom.ly/cxUm1WM

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mdj-journal.bsky.social @mdj-journal.bsky.social · 16/06/2026

Patients with isolated dystonia, but not those with combined, showed measurable improvement in speech/swallowing after DBS treatment, per a retrospective cohort study supported by MDS' Voice, Speech, and Swallowing Movement Disorders Study Group. loom.ly/Kg7Ae5c

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mdj-journal.bsky.social @mdj-journal.bsky.social · 05/06/2026

PD pathology frequently involves amyloid-β plaques, tau tangles and/or TDP-43 aggregates, in addition to misfolded α-synuclein. The @movedisorder Scientific Issues Committee reviewed how these multiple pathologies impact PD initiation and progression. loom.ly/9jx80CU

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mdj-journal.bsky.social @mdj-journal.bsky.social · 01/06/2026

Here is an insightful review article by Matarazzo and colleagues, highlighting the spectrum, frequency, and implications of co- and multi-pathologies in Parkinson’s disease. @matarazzomd loom.ly/9jx80CU

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mdj-journal.bsky.social @mdj-journal.bsky.social · 11/05/2026

Although deep brain stimulation for common movement disorders reliably improves motor symptoms, a new meta-analysis found that routine STN-DBS for PD resulted in significantly poorer speech intelligibility compared with medical therapy. loom.ly/-Fhesto

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mdj-journal.bsky.social @mdj-journal.bsky.social · 04/05/2026

Excellent viewpoint article on mitochondrial Parkinson's disease by Percetti and colleagues. loom.ly/sj3wYNs

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mdj-journal.bsky.social @mdj-journal.bsky.social · 23/04/2026

A key study by Andriolli and colleagues explores how D2 receptor activity within the indirect pathway contributes to the development of levodopa-induced dyskinesia and D2-agonist associated dystonia. loom.ly/TMnI4Co

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mdj-journal.bsky.social @mdj-journal.bsky.social · 07/04/2026

An international panel of neurologists, physiatrists, PTs, and clinimetricians found 10-Meter Walk Test and Modified Frenchay Scale to be useful first steps for evaluating lower and upper limb function, respectively, in patients with spastic paresis. loom.ly/Q58nang

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mdj-journal.bsky.social @mdj-journal.bsky.social · 03/04/2026

A study demonstrated that PD and MSA have distinct glymphatic free-water pathological profiles. An integrated model incorporating neuroimaging and clinical metrics showed excellent ability to differentiate PD from MSA, with an area under the curve of 0.994. loom.ly/vhmVFdY

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mdj-journal.bsky.social @mdj-journal.bsky.social · 01/04/2026

Recognizing which genetic dystonias are responsive to DBS is essential. In Woodhouse–Sakati syndrome, Alhodaif et al. evaluated five patients and reported an approximate 39% improvement in BFMDRS scores following bilateral GPi DBS. loom.ly/VLcx-VQ

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mdj-journal.bsky.social @mdj-journal.bsky.social · 25/03/2026

Many movement disorder rating scales in MDS’s portfolio are now digitalized in REDCap. These e-versions were developed through a structured, iterative process to ensure accuracy and quality. loom.ly/VCqfAj8

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mdj-journal.bsky.social @mdj-journal.bsky.social · 23/03/2026

A must-read (and watch) article by Bernardi and colleagues exploring the spectrum of ATP1A3-related movement disorders. The inclusion of a large number of outstanding videos makes it a true visual atlas of these conditions. loom.ly/6mLoFOA

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mdj-journal.bsky.social @mdj-journal.bsky.social · 03/03/2026

Changes in evidence standards call for more rigorous and modern clinical trials. Find out what that means for the latest assessment in medical treatments for ET. loom.ly/7b3mW9w

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mdj-journal.bsky.social @mdj-journal.bsky.social · 02/03/2026

A fitting tribute to Dr. Mark Hallett (1943–2025), one of the true giants in movement disorders and functional neurological disorder. This article introduces the proposed “Hallett sign”. loom.ly/u83Gj-4

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mdj-journal.bsky.social @mdj-journal.bsky.social · 20/02/2026

This important imaging study in Huntington’s disease (HD) reports significant subcortical iron accumulation and noradrenergic neuronal loss. A question for the future: What is the role of noradrenergic pathology in HD? loom.ly/dE06Y2Y

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mdj-journal.bsky.social @mdj-journal.bsky.social · 19/02/2026

An important case illustrating that REM sleep behavior disorder (RBD) does not necessarily signify an underlying alpha-synucleinopathy. Instead, it may arise from pathology involving the amygdala, with the clinical threshold potentially lowered by antidepressant use. loom.ly/E56j5nw

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mdj-journal.bsky.social @mdj-journal.bsky.social · 05/02/2026

A strength of the 2016 nomenclature proposal for genetically determined movement disorders is the delivery of relevant information by linking phenotype-genotype. However, with this comes possible subjectivity. Read more on the strengths and weaknesses. loom.ly/TV7jCRE

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mdj-journal.bsky.social @mdj-journal.bsky.social · 03/02/2026

This phenotypic heatmap of individuals diagnosed with NKX2-1-related disorders reports the presence of neurodevelopmental delay and chorea in 94% and 92% of cases, respectively. @movedisorder.bsky.social #PediatricSIG loom.ly/9xK-2Ys

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mdj-journal.bsky.social @mdj-journal.bsky.social · 28/01/2026

More than 80% of MSA patients report pain, making it important to identify the type of pain. In this large study of 157 MSA patients, the authors explored pain subtypes. The two most common types were directly related to autonomic dysfunction. loom.ly/pq0N3Mw

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mdj-journal.bsky.social @mdj-journal.bsky.social · 26/01/2026

This collaborative study (via DBSMatchMaker) demonstrates significant clinical improvement in patients with ADCY5-related disorder following bilateral GPi deep brain stimulation and represents the largest reported DBS case series in pediatric patients with this condition. loom.ly/JoHh2B8

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mdj-journal.bsky.social @mdj-journal.bsky.social · 20/01/2026

Here is an excellent review article on the medical treatment of essential tremor by Dash and colleagues. loom.ly/7b3mW9w

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mdj-journal.bsky.social @mdj-journal.bsky.social · 08/01/2026

Here is a large Dutch cohort study by Prooije and colleagues on SCA27B: loom.ly/JJFljvI Key takeaways: 1) Core features appear with GAA 200–249 expansions; 2) episodic SCA27B can mimic stroke 3) ~50% show benefit from 4-aminopyridine.

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mdj-journal.bsky.social @mdj-journal.bsky.social · 02/01/2026

An outstanding review, along with related correspondence, that emphasizes the “second-hit hypothesis” in peripherally induced movement disorders. loom.ly/LFOXbng

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mdj-journal.bsky.social @mdj-journal.bsky.social · 31/12/2025

Here is an insightful review by Lang and colleagues discussing LRRK2 as a potential disease-modifying target in sporadic Parkinson’s disease. loom.ly/41ob-eE

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mdj-journal.bsky.social @mdj-journal.bsky.social · 22/12/2025

This study from Brazil found subclinical, predominantly restrictive respiratory dysfunction in Friedreich’s ataxia. Compared with controls, patients had lower O₂ saturation, FVC, and FEV₁. loom.ly/xomEySI

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mdj-journal.bsky.social @mdj-journal.bsky.social · 02/12/2025

In this clinical trial (PREMANDYSK) by Rascol and colleagues, early addition of 200 mg/day of amantadine IR to levodopa in patients with early PD, before the onset of motor complications, reduced the incidence of levodopa-induced dyskinesia by an average of 50%. loom.ly/gIMI7X0

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mdj-journal.bsky.social @mdj-journal.bsky.social · 26/11/2025

In this randomized, double-blind, placebo-controlled study, propranolol (titrated up to 240 mg/day) produced a significantly greater reduction in tremor than placebo in individuals with SCA12. loom.ly/zKIxli4

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mdj-journal.bsky.social @mdj-journal.bsky.social · 24/11/2025

Is constipation in Parkinson’s disease associated with a higher burden of neuroinflammation? In this study, Camacho & colleagues found that early-stage PD patients with constipation showed markedly greater uptake of microglial activation markers across multiple brain regions. loom.ly/NxlNkpo

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mdj-journal.bsky.social @mdj-journal.bsky.social · 14/11/2025

Digital health technology can measure symptom severity for gait, tremor, bradykinesia, etc. MDS's Technology Study Group systematically reviewed the application of these devices in clinical trials of levodopa, other PD drugs. loom.ly/Y3FT_9U

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mdj-journal.bsky.social @mdj-journal.bsky.social · 05/11/2025

Kaplan–Meier analysis supported strong predictive value of a concise patient-reported MDS-UPDRS for dopaminergic initiation in early PD, underscoring patients’ central role in clinical decisions involving functional limitations. #COAProgram loom.ly/HFNAJUE

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mdj-journal.bsky.social @mdj-journal.bsky.social · 28/10/2025

According to SynNeurGe criteria, the latest MDSGene literature review found that the PARK-RAB32 form of PD can be classified as S+ (evidence of synucleinopathy), N+ (neurodegeneration supported by imaging data), and GP+ (presence of a genetic variant). loom.ly/RWajhfA

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mdj-journal.bsky.social @mdj-journal.bsky.social · 22/10/2025

Insightful article by Paparella and colleagues exploring the Bradykinesia complex (bradykinesia+ hypokinesia+ dysrhythmia+ sequence effect) in Parkinson's disease. loom.ly/FdlR_8g

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mdj-journal.bsky.social @mdj-journal.bsky.social · 20/10/2025

Great study by Wilken et al. showing that basal ganglia theta activity correlates with the onset of dyskinesia — a finding that could shape future adaptive DBS approaches. loom.ly/CgFd3AE

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mdj-journal.bsky.social @mdj-journal.bsky.social · 22/09/2025

Dystonia + ataxia with brain iron accumulation on imaging? Don’t forget to keep SCA50 in the differential. loom.ly/ETrE17Q

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mdj-journal.bsky.social @mdj-journal.bsky.social · 10/09/2025

New population-based study from Sweden: Maternal TS/CTD is linked to higher risks of gestational diabetes and both elective & emergency C-sections, highlighting important pregnancy and neonatal outcome associations. loom.ly/o5oUT8w

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mdj-journal.bsky.social @mdj-journal.bsky.social · 27/08/2025

An interesting study by Wang and colleagues concludes that PD and MSA-P have compromised AQP4 polarization, impairing glymphatic function, which is consistent with the known neuroimaging changes demonstrated by free-water imaging. loom.ly/xpqlC8s

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mdj-journal.bsky.social @mdj-journal.bsky.social · 25/08/2025

In this interesting study, Kersebaum and colleagues provide electrophysiological evidence of impaired central pain modulation in PD patients. The key finding is a reduced habituation to repetitive noxious stimuli. loom.ly/kIDB6Io

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