mdcp-journal.bsky.social @mdcp-journal.bsky.social · 4hExpertise exists. Access doesn’t always follow. Across Latin America, children with movement disorders face highly variable access to genetic testing, imaging, DBS, medications and emerging targeted therapies. loom.ly/U9xicg0 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 07/10/2026Same UPDRS improvement. Different motor physiology? Both L-dopa and STN-DBS improved finger-tapping scores in PD, but kinematics told a more interesting story: -L-dopa → fewer hesitations -STN-DBS → fewer interruptions -Sequence effect → improved by neither loom.ly/1dl5nk8 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 30/09/2026Your patient is motorically ON. But are they neuropsychiatrically ON? This excellent review reframes neuropsychiatric fluctuations in PD as dynamic, dopamine-linked phenomena that may precede, exceed or occur independently of motor fluctuations. loom.ly/Ow7EwZI 100
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 28/09/2026Greater baseline impairment and a larger CSF drainage response on TUG and 10-m walk were independently associated with greater post-shunt gait improvement. Stationary balance and functional endurance measures did not show the same association with surgical outcomes. loom.ly/0V3_wh4 001
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 23/09/2026Have we been dismissing groaning in PSP as a curiosity instead of a symptom? This large cohort study suggests groaning is associated with: -More severe disease -Worse cognitive-behavioural dysfunction -Greater functional dependence -Higher caregiver burden loom.ly/_4frBmY 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 21/09/2026A post-void residual may tell you more than another scan. This practical review reframes lower urinary tract symptoms as diagnostic clues in parkinsonism: Storage symptoms → usually PD Early retention or PVR >100 mL → think MSA Urge incontinence + magnetic gait → think NPH loom.ly/4xeEseE 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 17/09/2026New MDCP Clinical Pearl: High Prevalence and Clinical Impact of Fibromyalgia in Functional Motor Disorder doi.org/10.1002/mdc3.70674 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 16/09/2026This real-world study found that overnight foslevodopa/foscarbidopa infusion improved nocturia, urinary symptoms and quality of life after 3 months of treatment. Don't just ask about OFF periods. Ask about nights. loom.ly/KsbAdOk 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 09/09/2026This review makes a compelling case that "Breathe, Eat, Talk" should become a routine part of every movement disorders assessment. 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 09/09/2026We measure tremor. We score bradykinesia. We quantify rigidity. But what about the symptoms that often determine whether a patient can safely eat, communicate with family, or avoid aspiration pneumonia? loom.ly/_2L4COE 100
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 07/09/2026This case highlights 3-O-methyldopa (3-OMD) as a potential culprit, competing for LAT1 transport at the blood-brain barrier. COMT inhibition with opicapone dramatically reduced 3-OMD and improved motor symptoms. A reminder that plasma levodopa ≠ central levodopa availability. loom.ly/VkP2H5Q 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 04/09/2026Viewpoint by the MDS Scientific Issues Committee deconstructs past reporting on levodopa use by patients with PD and the relative risk for developing melanoma to clarify a contemporary evidence-based clinical approach. loom.ly/giFoveM 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 03/09/2026The level of diagnostic precision in clinical neurological assessments of speaking or swallowing dysfunction is often insufficient. Early referral to speech-language pathology can reduce such day-to-day complications in people living with movement disorders. loom.ly/_2L4COE 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 02/09/2026Does PD reduce creativity? Maybe not. 5 professional artists living with PD, all reported changes in technique or style, but none felt their creativity had diminished. Instead, they adapted to motor fluctuations, changed their tools, and continued creating meaningful work. loom.ly/Raw6lYg 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 27/08/2026A patient with PD and prior melanoma needs levodopa. What do you tell them? According to this viewpoint: -Melanoma history does not automatically preclude levodopa use -No convincing evidence that levodopa promotes melanoma -Continue routine dermatological surveillance loom.ly/giFoveM 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 25/08/2026Have we been asking the wrong question? Exercise is one of the best interventions we have for Parkinson's disease. Yet this meta-analysis found no measurable effect on levodopa-induced dyskinesia or wearing-off. Maybe the issue isn't that exercise doesn't work... loom.ly/DxK8p2w 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 21/08/2026This case highlights a patient with EOPD carrying two major genetic risk factors: a 22q11.2 microdeletion and a pathogenic GBA1 mutation. The authors propose that cumulative genetic burden may help explain an onset far earlier than expected for either variant alone. loom.ly/m_J26RE 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 13/08/2026Could the spinal cord be a therapeutic target in refractory status dystonicus? Sometimes the next breakthrough is not another brain target, but a spinal one! loom.ly/VRdO-lE 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 11/08/2026Patient on foslevodopa/foscarbidopa infusion. Levodopa levels look fine. OFF periods persist. What are you missing? This case highlights 3-O-methyldopa (3-OMD) as a potential culprit, competing for LAT1 transport at the blood-brain barrier. loom.ly/AxHmv3Y 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 07/08/2026Can we identify patients at risk for a first fall before it occurs? Using routinely collected motor and cognitive data from clinic visits, we developed and validated a model to estimate first-fall risk in Parkinson’s disease, supporting earlier, proactive clinical assessment. loom.ly/F7Oxh14 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 03/08/2026As biomarker-driven diagnosis of prodromal PD becomes reality, are patients ready to know their risk? In a study of 1,385 participants, 88% of people with iRBD wanted future risk disclosure—even without disease-modifying treatments. Yet only 32% would join clinical trials. loom.ly/7him1EU 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 29/07/2026Subtle dystonia is almost universal in surgical tremor patients—even those labeled “essential tremor.” Blinded video study (n=30) after Vim-HiFU: no overall post-procedure worsening of dystonia severity. Clinically meaningful new dystonia occurred in only ~1–2%. loom.ly/KheDz9A 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 27/07/2026New pilot RCT data: Online mindfulness-based intervention for tics (MBIT) reduced comorbid Obsessive Compulsive symptoms vs psychoeducation/relaxation/supportive therapy in adults with Tourette's syndrome. A promising accessible option for the common TS+OC phenotype. loom.ly/WGwykPk 010
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 23/07/2026The heart may diagnose PD before the brain. Cardiac sympathetic imaging isn't just a confirmatory test: -PD+OH vs MSA-P -Predicts phenoconversion -Supports body-first PD -Identifies "sick-but-not-dead" neurons Time to view cardiac denervation as a biomarker, not a bystander. loom.ly/Tg3LNiA 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 21/07/2026Children with primary complex motor stereotypies show reduced psychosocial HRQoL — but stereotypy severity doesn’t predict it. ADHD + anxiety symptoms do. Screen & treat comorbidities! loom.ly/1hoVXSg 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 21/07/2026Congratulations to everyone who played a part in increasing our score. Your contributions are informing clinical practice and improving care across the world. loom.ly/GGH0SWU 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 15/07/2026DBS in PD: The hidden cost Half of patients report major communication decline after STN-DBS — even when formal language tests look fine. CPIB catches what objective measures miss! Counsel aggressively. Track patient-reported outcomes. Real life > test scores. loom.ly/RBZlks4 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 13/07/2026Tremor conundrum in clinic? Functional vs Organic just got clearer! New systematic review & meta-analysis in MDCP: Electrophysiology helps rule in functional tremor with high specificity (93%) — overall sens 63%, but test batteries shine (sens up to 100%, spec up to 98%)! loom.ly/yDTWldQ 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 09/07/2026Parkinsonism in KMT5B-related neurodevelopmental disorders: expanding the spectrum. This case shows de novo KMT5B variant causing ID, autism, dysmorphism & psychiatric issues + progressive parkinsonism with DaTSCAN-confirmed nigrostriatal loss. loom.ly/xYT8Ebs 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 07/07/2026Chorea + cerebellar ataxia? Think beyond isolated syndromes. This highlights key genetic overlaps: SCA17, HD, DRPLA, A-T, Wilson's, NPC, GLUT1 & more — with distinctive clues (oculomotor, systemic, MRI) & a clear stepwise diagnostic algorithm prioritizing treatable causes. loom.ly/9xVt4M8 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 01/07/2026Hyperkinetic movement disorders commonly co-exist with neurodevelopmental syndromes and epileptic encephalopathies. This review expertly reviews clinical (neurological AND non-neurological) features which can help guide genetic testing! loom.ly/_N6XdFQ 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 29/06/2026Suboccipital muscles are often the hidden drivers of retrocaput, torticaput & dynamic caput tremors in cervical dystonia. This practical ‘How Do I’ with video demonstration, clear anatomy, COL-CAP indications & technique pearls details EMG-guided injection of these muscles. loom.ly/imF8JXY 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 11/06/2026Key lessons from molecular imaging in genetic PD: • Changes detectable before symptoms • Non-dopaminergic systems matter early • Patterns differ by mutation (GBA vs LRRK2 etc.) Imaging may guide prognosis, cognition & treatment choices loom.ly/sleSJiw 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 02/06/2026PD is a disease of uncertainty, and intolerance of uncertainty drives anxiety, avoidance & ↓QoL. Clinicians: ask about it! It’s modifiable: CBT/ACT/mindfulness may help. Treat the uncertainty, not just the motor symptoms loom.ly/5kOko2o 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 28/05/2026New MDCP Pearl: Computer Vision Analysis for Objective Motor Assessment in Parkinson's Disease: A Retrospective Study loom.ly/5kOko2o 001
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 21/05/2026Motor improvement ≠ life improvement. After STN-DBS, patients rated real-world functioning ~7.7/10—yet genetics (GBA) and sex tracked more with socio-occupational outcomes than the usual clinic scores. We need outcomes that reflect living, not just moving. loom.ly/JkeP8t4 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 19/05/2026Cervical dystonia has 2 big phenotypes: -Early onset (35y) = much worse pain/mood/QoL vs later onset (48y) — motor severity differences are smaller. -Don’t “BoNT-and-bye”: treat the non-motor load. loom.ly/C2cZIOc 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 14/05/2026PD & fractures: we’re missing the mark. Only 12% on bone protection pre-fracture → just 53% @48wks post-fracture. -Men, rib #, care home residents = least treated -Vertebral # drives treatment—but shouldn’t be the trigger -Think bone health EARLY in Parkinson’s loom.ly/CN43aPUmovementdisorders.onlinelibrary.wiley.comMind the Gap: Predictors of Osteoporosis Treatment Following Fragility Fracture in ParkinsonismBackground Fracture risk is increased in Parkinson's yet this risk is often not addressed. Objectives Our objective was to study the extent to which osteoporosis was treated, and predictors of tre... 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 12/05/2026The Japanese anime character Naruto Uzumaki has for generations inspired children and adults. in this study Naruto's running style was observed and described in children and interpreted as a evidence of a cultural meme rather than a pathological disorder of movement. loom.ly/hclviEI 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 07/05/2026Continuous subcutaneous apomorphine infusion (CSAI) may benefit selected patients with multiple system atrophy. In a French multicenter cohort (n=50), CSAI improved motor symptoms in 90% at 6 months, with acceptable tolerability. #MSA #Parkinsons #DAT #Apomorphine loom.ly/BL2WFJo 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 05/05/2026Among PDRD patients with significant palliative needs, nearly half had an ED visit and one in five were hospitalized annually. Home-based services were used by over a third. Acute care use remains substantial underscoring gaps in supportive care delivery. loom.ly/ni_LYAc 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 01/05/2026Foslevodopa/foscarbidopa improves urinary disturbances, nocturia and quality of life in PD patients. Both overnight continuous dopaminergic stimulation and increasing the total dose of L-dopa contribute to improve overactive bladder. loom.ly/7apCuI8 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 29/04/2026The 'Swallow Tail Sign' gets an upgrade! Absence of dorsolateral nigral hyperintensity on SMWI is a robust, reproducible marker of neurodegenerative parkinsonism—works early, survives real‑world controls, and fits existing MRI pathways! loom.ly/VaFEiNw 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 27/04/2026MRgFUS thalamotomy shows strong tremor control even in patients ≥80 — with 95.6% improving and side‑effect rates similar to younger adults. Learning point: Age alone shouldn’t exclude MRgFUS; balance issues are common but usually improve or resolve. loom.ly/TaVJnSw 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 23/04/2026Two siblings with BCL11B‑related early‑onset dystonia showed striking, long‑lasting motor improvement after GPi‑DBS,with >50% BFMDRS-M reduction. A reminder that genetic dystonias can be highly DBS‑responsive—mutation type, phenotype & timing matter. loom.ly/jdqaE90 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 21/04/2026Exocrine dysfunction in PD is common & early—drooling, dry mouth/eyes, seborrhea, rhinorrhea, sweating & GI issues all reflect autonomic + α‑synuclein pathology. Clinician tip: Ask about these symptoms—they’re underrecognized but highly impactful! loom.ly/f8qhIg4 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 17/04/2026Subcutaneous foslevodopa/foscarbidopa (fLD/fCD) was thought to overcome systemic and nutritional complications of LCIG therapy, but peripheral neuropathy can still emerge. Baseline + ongoing vitamin & nerve monitoring recommended! loom.ly/ZhfwsWM 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 15/04/2026New scoping review highlights how FXTAS remains under diagnosed in Latin America. loom.ly/YRyRVdg 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 10/04/2026A global MDS member survey on career and work environment found pronounced gender disparities in the field. Data were proportionally representative of Pan-America, Asia-Oceania, Europe, and Africa. loom.ly/G1b2SQo 000
mdcp-journal.bsky.social @mdcp-journal.bsky.social · 09/04/2026New case series:In PD dementia,cognitive fluctuations were consistently time‑locked to hypotensive episodes on 24‑hr BP monitoring — independent of levodopa timing. Recognizing & treating hypotension may be key to improving cognition. loom.ly/p938aJImovementdisorders.onlinelibrary.wiley.comJust a moment...New case series:In PD dementia,cognitive fluctuations were consistently time‑locked to hypotensive episodes on 24‑hr BP monitoring — independent of levodopa timing. Recognizing & treating hypotension may be key to improving cognition. 000
