Sign in

Melvin Chan

@mchanmd.bsky.social
667 followers 855 following 107 posts

Current NSMC Faculty, CU Ped Neph, and IM faculty; interested in CKM and transition of care

PostsRepliesMedia
Melvin Chan @mchanmd.bsky.social · 05/10/2026
Look at this great Skeetorial!
010
Reposted by Melvin Chan
kireports.bsky.social @kireports.bsky.social · 17/09/2026
🚨 #Tweetorial alert🚨- brought to you by @kireports.bsky.social @theisn.org #NephTwitter Not all preeclampsia (PE) is the same. New data on isolated PE vs. PE-HELLP syndrome—and why close monitoring matters for patients' cardiovascular and kidney health www.kireports.org/article/S246...
176
Melvin Chan @mchanmd.bsky.social · 09/09/2026
One of the aged old questions, what do you do about persistent hematuria? This post may answer that! @elbaonelida.bsky.social
010
Melvin Chan @mchanmd.bsky.social · 02/09/2026
Learn more about how donor and recipient diabetic status impact kidney graft function! Great job @manoleaandreea.bsky.social
021
Melvin Chan @mchanmd.bsky.social · 01/03/2026
It is officially March 1, and you know what that means!! #NephMadness! @nephmadness.bsky.social Learn more here: ajkdblog.org/2026/03/01/w...
media.tenor.com
a man is smiling and saying it 's madness
ALT: a man is smiling and saying it 's madness
031
Melvin Chan @mchanmd.bsky.social · 14/01/2026
Excellent job #NephJC interns!!
media.tenor.com
a picture of a puppy with the caption who 's awesome
ALT: a picture of a puppy with the caption who 's awesome
060
Melvin Chan @mchanmd.bsky.social · 14/01/2026
I have only used this medication in a few patients. But it is interesting that it caused hypotension in one of my patients that I had to stop her ACE. When I looked at Lexicomp for PNH, it said hypertension. But a few of the experts had seen this AE before. #NephJC
ae.in
050
Melvin Chan @mchanmd.bsky.social · 14/01/2026
I asked Dr Dixon (my mentor) about sequential complement blockade before and he said he would be really concern about the infectious risk but def a future study to look at #NephJC
030
Melvin Chan @mchanmd.bsky.social · 14/01/2026
Agree! We have so many complement therapies now but not enough markers for continued monitoring. A selfish plug but our working group did a review on those biomarkers #NephJC: pubmed.ncbi.nlm.nih.gov/41404698/
pubmed.ncbi.nlm.nih.gov
Biomarkers in the Management of Complement-Mediated Kidney Diseases in the Era of Complement Therapeutics - PubMed
Pharmacologic complement inhibition offers a promising therapeutic strategy for several complement-mediated kidney diseases. Yet, at present, nephrologists must rely on an incomplete toolkit of histopathologic and circulating biomarkers to assess complement activity in complement-mediated kidney dis …
140
Melvin Chan @mchanmd.bsky.social · 14/01/2026
Love this trial, included pediatric data! @rheaultm.bsky.social is smiling now. #NephJC
media.tenor.com
a little girl wearing a leopard print shirt is making a face
ALT: a little girl wearing a leopard print shirt is making a face
040
Melvin Chan @mchanmd.bsky.social · 14/01/2026
Yeah I am actually surprised at how receptive people have been when I prescribe it to my Peds patients. Granted I give them Emla cream to use. I have people prefer subQ over oral Wegovy on the adult side. #NephJC
030
Melvin Chan @mchanmd.bsky.social · 14/01/2026
I remember learning about MPGN in my First Aid book and it made no sense. Glad they changed it! How many of yall have seen C4GN? Just learning about it now #NephJC
130
Melvin Chan @mchanmd.bsky.social · 14/01/2026
Late to the game but a pediatric nephrologist here in CO. No COI #NephJC
140
Melvin Chan @mchanmd.bsky.social · 14/01/2026
Can’t wait for this discussion. Already have a few patients on it and have been going well! #NephJC
050
Melvin Chan @mchanmd.bsky.social · 18/12/2025
New phase 3 data from the ATTAIN-MAINTAIN trial. #NephSky #Obesity #GLP1 lilly.mediaroom.com/2025-12-18-L...
032
Melvin Chan @mchanmd.bsky.social · 18/12/2025
The future of nephrology
023
Reposted by Melvin Chan
Sarah Sanghavi @sarahsanghavi.bsky.social · 12/12/2025
Appreciate this excellent work showing GLP-1 agonists reduce mortality in patients on dialysis and improve their chances of receiving a transplant. Hopefully, it will help me get them approved for my patients through the VA. #nephsky journals.lww.com/cjasn/pages/...
062
Reposted by Melvin Chan
Michelle Rheault, MD @rheaultm.bsky.social · 08/12/2025
Congenital and infantile nephrotic syndrome: genotype-phenotype associations pubmed.ncbi.nlm.nih.gov/41339767/
063
Melvin Chan @mchanmd.bsky.social · 07/12/2025
Thrilled to have our review article on complement-mediated biomarkers published #NephSky journals.lww.com/cjasn/abstra...
021
Melvin Chan @mchanmd.bsky.social · 04/12/2025
Excited to match two amazing nephrology fellows for next year! @childrenscolo.bsky.social
010
Melvin Chan @mchanmd.bsky.social · 30/11/2025
More evidence showing that GLP1s may be modulate rheumatic disease #MedSky #NephSky: rheumatology.org/press-releas... and pubmed.ncbi.nlm.nih.gov/40994310/
pubmed.ncbi.nlm.nih.gov
Glucagon-Like Peptide-1 Receptor Agonist Use and the Risk of Adverse Cardiac and Kidney Outcomes Among Patients with Systemic Lupus Erythematosus and Lupus Nephritis - PubMed
We found lower risks of adverse CV and kidney outcomes and mortality with GLP-1RA use compared with DPP4i use among patients with lupus and T2D.
010
Melvin Chan @mchanmd.bsky.social · 20/11/2025
More tools for our advanced CKD patients!
011
Reposted by Melvin Chan
Michelle Rheault, MD @rheaultm.bsky.social · 08/11/2025
Late breakers that included children: ✅Setanaxib in Alport (12+) Late breakers that did NOT include children: 🚫Atacicept in IgAN 🚫CONFIDENCE 🚫PISCES: Fish oil in Dialysis 🚫LIBERATE-D 🚫balcinrenone + dapa 🚫Obintuzumab in lupus nephritis 🚫Sibeprenlimab in IgA 🚫MIL62 in membranous +more #KidneyWk
12012
Melvin Chan @mchanmd.bsky.social · 29/10/2025
How many people see HSP as a spectrum of IgAN? Feel like most in the pediatric world see HSP more acutely and if persists past a year treat it like IgAN #NephJC
021
Melvin Chan @mchanmd.bsky.social · 29/10/2025
The one other caveat about children is they tend to have more acute lesions like crescents. That is one major difference reasons why in pediatrics we are more aggressive with immunosuppression #NephJC
020
Reposted by Melvin Chan
Nephrology Journal Club @nephjc.bsky.social · 29/10/2025
🎨Beautiful visual abstract by Dr Natalia Nombera @roxnonna23.bsky.social #NephJC www.nephjc.com/news/...
0106
Melvin Chan @mchanmd.bsky.social · 29/10/2025
Late at joining, Melvin here in CO, no COI #NephJC
020
Melvin Chan @mchanmd.bsky.social · 26/10/2025
Great read on ways of measuring renal function. Shout out to @elbaonelida.bsky.social www.kireportscommunity.org/post/towards...
kireportscommunity.org
Towards new ways of assessing kidney function. Where to look to improve?
Written by Elba MedinaReviewed by Brian Rifkin;Sophia AmbrusoToday, current methods for measuring kidney function, due to several critical limitations, need to be reimagined. In the reimagining Kidney...
031
Melvin Chan @mchanmd.bsky.social · 02/10/2025
A great read on the history and upcoming anticoagulation targets especially for our dialysis patients! #NephSky www.kireportscommunity.org/post/bleedin...
kireportscommunity.org
Bleeding, Clotting, and Kidney Disease in Atrial Fibrillation: Can Factor XI Inhibitors Change the Game?
Explore how we are uncoupling hemostasis and thrombosis via Factor XI inhibitors and how it is may change anticoagulation for atrial fibrillation in kidney disease
022
Melvin Chan @mchanmd.bsky.social · 28/09/2025
Looks like tirzepatide have benefits for those with T1DM, with insulin needs reduced within 2 weeks of treatment. #NephSky #MedSky www.medscape.com/viewarticle/...
medscape.com
First Randomized Trial of Tirzepatide in T1D Shows Benefits
Tirzepatide reduced weight, A1c, and insulin dose in type 1 diabetes in a small randomized controlled trial.
042
Melvin Chan @mchanmd.bsky.social · 19/09/2025
So exciting! Also it’s a non peptide form so you don’t have to fast!
010
Melvin Chan @mchanmd.bsky.social · 17/09/2025
Yup! Especially if it synchronizes with telmisartan. Only barrier is the cost of it. But hopeful it will come down, especially with oral formulations coming out in 1-2 years! Orfoglipron showing 13% weight loss and no need to fast! #NephJC
020
Melvin Chan @mchanmd.bsky.social · 17/09/2025
Wonderful job team!! #NephJC
media.tenor.com
two cartoon characters giving each other a high five in front of a blue background that says high five
ALT: two cartoon characters giving each other a high five in front of a blue background that says high five
020
Melvin Chan @mchanmd.bsky.social · 17/09/2025
That’s really interesting. I wonder why? Feel like most PCP I see still use lisinopril the most and then use ARB #NephJC
110
Melvin Chan @mchanmd.bsky.social · 17/09/2025
I refer to Dr Rifkin. One of the reasons I didn’t choose adult nephrology
media.tenor.com
a baby is making a funny face with his mouth open
ALT: a baby is making a funny face with his mouth open
010
Melvin Chan @mchanmd.bsky.social · 17/09/2025
Do people have specific ACE/ARBs they prefer? Seems like olmesartan has been the most popular why, not sure why though. #NephJC
370
Melvin Chan @mchanmd.bsky.social · 17/09/2025
Agree feels like this is overly complicated and will decrease adoption of these guidelines #NephJC
020
Melvin Chan @mchanmd.bsky.social · 17/09/2025
That’s great! For those who use ABPMs regularly, how often do you repeat? #NephJC
130
Melvin Chan @mchanmd.bsky.social · 17/09/2025
I saw those but feels a bit overkill. Maybe if there blood pressure is severe or needing multiple drugs? #NephJC
000
Melvin Chan @mchanmd.bsky.social · 17/09/2025
Feel like it may add a lot of anxiety especially because I assume the reads are based on the wrist? #NephJC. Funny personal story, my dentist used to always charge me $10 when they checked my wrist BP during clean. I debated with them and now they have a big FYI not to do BP check for me.
020
Melvin Chan @mchanmd.bsky.social · 17/09/2025
That’s great! I feel like moving away from it is a big loss especially with missing nocturnal hypertension #NephJC
010
Melvin Chan @mchanmd.bsky.social · 17/09/2025
How many nephrologist still do 24 hour monitoring? When I talk with adult doctors they seem to moving away from it #NephJC
620
Melvin Chan @mchanmd.bsky.social · 17/09/2025
Prior to the last 5 years, in pediatrics, we only correlated HTN with LVH, cIMT, pWV. But now we have hard outcomes including one from JAMA #NephJC jamanetwork.com/journals/jam...
jamanetwork.com
High Blood Pressure in Childhood and Premature Cardiovascular Disease Mortality
This cohort study examines the association of elevated blood pressure at age 7 years with cardiovascular disease mortality later in life.
030
Melvin Chan @mchanmd.bsky.social · 17/09/2025
Your travel adventures are always so crazy. What was your longest travel time?
020
Melvin Chan @mchanmd.bsky.social · 17/09/2025
Melvin, Peds Nephrology in CO, interested in cardiorenal syndrome. No COI. Looking forward to the discussions #NephJC
220
Melvin Chan @mchanmd.bsky.social · 17/09/2025
Do most nephrologist prescribe GLP1? Here in the US, there’s a lot of financial obstacles to get it
000
Reposted by Melvin Chan
Nephrology Journal Club @nephjc.bsky.social · 15/09/2025
Change is in the Autumn air 🌬️🍂 Join use only on #Bluesky on 9/16/25 at 9pm EST. We're discussing the 2025 ACC/AHA Hypertension Guideline Update. 🫀🫘🧠 #NephSky #MedSky www.nephjc.com/news/accaha2025-klno3
nephjc.com
PREVENT, Detect, Treat: What’s New in the 2025 Hypertension Toolkit — NephJC
This week, we will discuss the AHA/ACC 2025 hypertension guideline update. Wow, have eight years flown by?
01713
Melvin Chan @mchanmd.bsky.social · 14/09/2025
There’s continued growing evidence that childhood onset hypertension leads to worse outcomes.
000
Melvin Chan @mchanmd.bsky.social · 11/09/2025
Totally agree with you @hswapnil.medsky.social. Just to add controversy, there was a recent abstract in Europe that showed CV benefits regardless of weight loss in a sub-analysis of SELECT (ie those losing than 5% weight). I can't find the publication but here is an article: easo.org/semaglutide-...
easo.org
Semaglutide: 4-Year Weight Loss and Cardiovascular Benefits - EASO
Two important studies based on the largest and longest clinical trial of the effects of semaglutide on weight in over 17,000 adults with overweight and obesity but not diabetes find patients lost on a...
011
Melvin Chan @mchanmd.bsky.social · 11/09/2025
Thoughts about Wegovy vs Zepbound for MACE Reduction? #MedSky #NephSky Finding: -Semaglutide showed 29% reduction in MACE Limits: -Small # of events -Retrospective Implications: -Wegovy may be better for those with ASCVD -Does GIP have any CV benefits? sciencehub.novonordisk.com/content/dam/...
sciencehub.novonordisk.com
120