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Maximilian Heeg

@maximilian.heeg.io

Posts Replies Media

Maximilian Heeg @maximilian.heeg.io · 01/10/2026

We’ve released SpatialTRACE and its code! Annotate a few structures, map anatomical axes and regions across spatial transcriptomics, then carry those maps into microscopy. Watch the video to see it in action 👇 Shoutout to @amonell.bsky.social for leading this work! www.biorxiv.org/content/10.6...

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Maximilian Heeg @maximilian.heeg.io · 22/01/2025

🧵 4/10 This diversity is regulated by: 1. Distinct ligand-receptor activities 2. Spatial cytokine gradients 3. Specialized cellular contacts creating a complex molecular landscape that guides TRM differentiation

Specialized cellular contacts create a complex molecular landscape that guides TRM differentiation. Cells in the small intestine are colored by cell type and connected to their neighboring cells.

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Maximilian Heeg @maximilian.heeg.io · 22/01/2025

🧵 2/10 Using spatial transcriptomics (Xenium & MERSCOPE), we discovered that intestinal TRM cells occupy distinct niches that shape their phenotype and function. We developed computational approaches to map cells along three anatomical axes 📊

Each cell is colored according to its positions along the 3 main axes (crypt to villus, epithelial distance and longitudinal).

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