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Reposted by Manuel Matzinger

Alejandro Brenes @ajbrenes.com · 16/06/2026

New preprint out! We benchmarked SCP workflows across instruments, software and library strategies. We compare DIA-software, search parameters, quantification precision and quant reliability across 3 cell types: large A549, medium RKO, and the very challenging ex-vivo peripheral blood neutrophils.

biorxiv.org

The Single Cell Proteomic blueprint, navigating instrumentation platforms, software tools and high-load libraries in neutrophils, RKO and A549 cells

Mass spectrometry-based single cell proteomics (SCP) is rapidly emerging as a powerful approach for biological research, with applications extending beyond in-vitro cancer cell lines. Recent advances ...

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Reposted by Manuel Matzinger

IonOpticks @ionopticks.com · 31/03/2026

NOW PUBLISHED: Lowering FAIMS resolution on the Orbitrap Astral increases peptide identifications by 6-18% across sample loads from 250 pg to 16 ng, as demonstrated in new research from the Mechtler lab using Aurora Rapid 8×75 XT columns: bit.ly/4s0GELj @matzingerm.bsky.social @impvienna.bsky.social

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Manuel Matzinger @matzingerm.bsky.social · 30/09/2025

I feel truly honored!😊 Thank you so much to everyone who contributed to our efforts in performing single cell proteomics at the Vienna BioCenter. Thank you so much also to the APMA selection committee for promoting our work (and those of many other talented young scientists)!

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Manuel Matzinger @matzingerm.bsky.social · 16/08/2025

Excited to share our latest in vivo crosslinking workflow using a dual enrichment strategy: Over 5000 crosslinks and 56 novel PPls- Huge thanks to the amazing team: Philipp Bräuer, Laszlo Tirian, Fränze Müller, Karl Mechtler at the Vienna BioCenter who made this possible! doi.org/10.1038/s420...

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Manuel Matzinger @matzingerm.bsky.social · 25/07/2025

The deadline to submit abstracts and register for this years symposium on single cell proteomics #ESCP25 in Vienna is approaching this Sunday! This year we additionally host a workshop for deep visual proteomics and a Thermo User Meeting.

apma.at

6th ESCP 2025 – APMA

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Manuel Matzinger @matzingerm.bsky.social · 04/03/2025

Excited to unveil our new, efficient & easy to implement workflow for in vivo XL-MS! 🎉 It delivers a comprehensive PPI network already from a single fraction measurement, saving valuable MS time and resources. www.biorxiv.org/content/10.1...

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Reposted by Manuel Matzinger

European Research Council (ERC) @erc.europa.eu · 08/02/2025

What do Europeans think of science and technology? - 83% believe science and tech have a positive impact, - 67% say science makes life easier, healthier and more comfortable, - 58% want to learn more about scientific advances. Find out more in the new Eurobarometer. ec.europa.eu/commission/p...

ec.europa.eu

Europeans strongly support science and technology according to new Eurobarometer survey

The latest Eurobarometer survey on ‘European citizens' knowledge and attitudes towards science and technology' released today shows more than 8 in 10 citizens (83%) think that the overall influence of...

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Reposted by Manuel Matzinger

Vienna BioCenter @viennabiocenter.bsky.social · 16/01/2025

Learn more about a new single-cell proteomics workflow that enables an unprecedented level of protein quantification at the single-cell level developed at the Proteomics Tech Hub at Vienna BioCenter lnkd.in/dMR55uRw

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Reposted by Manuel Matzinger

IonOpticks @ionopticks.com · 02/12/2024

Biggest challenge facing the proteomics community? To Manuel Matzinger, Senior Scientist & Deputy Head, Proteomic Technology Hub, Vienna BioCenter - it’s controlling false discovery rate. Manuel discusses his journey into the field, his One-Pot Workflow & the role of technology. Read his feature:

linkedin.com

Quality over quantity: How Manuel Matzinger is challenging the ‘race for high numbers’

Manuel Matzinger, Senior Core Scientist and Deputy Head of the Proteomic Technology Hub at the Campus Vienna BioCenter, is pushing the boundaries of single-cell proteomics by combining the latest MS t...

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Reposted by Manuel Matzinger

kmechtler.bsky.social @kmechtler.bsky.social · 21/11/2024

It gives me great pleasure to announce our next European Single Cell Proteomics Conference www.apma.at/6thescp/ We would be delighted to receive many abstracts from students so that they have the opportunity to give their first presentation. On behalf of: Erwin, Fabian, Manuel, Fabian and Karl

apma.at

6th ESCP 2025 – APMA

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