Happy to share our article published in @embomolmed.org in which we demonstrate that the repressor Capicua acts as a natural barrier to lung tumor development driven by Kras/Trp53 mutations. You can read it here: www.embopress.org/doi/full/10....
embopress.org
The repressor Capicua is a barrier to lung tumor development driven by Kras/Trp53 mutations | EMBO Molecular Medicine
imageimageThe inactivation of the repressor Capicua (CIC) promotes the development of lung cancer
in Kras/Trp53 mutant mice by transforming bronchiolar Club cells. Loss of CIC in lung cancer cells
cau...
