iiinova — where your digital self keeps evolving

Matteo Ferla @matteoferla.bsky.social · 31/10/2025

Ghoulish calculations? Sounds like a job for an RTX6666

Matteo Ferla @matteoferla.bsky.social · 17/08/2025

I wrote a blogpost ( blog.matteoferla.com/2025/08/conf... ) about a potential aid to crystallography thought up when I worked w/ @xchem.bsky.social: generating a fake crystal lattice from a protein model in order to design optimal crystal contacts with ProteinMPNN. #ProteinDesign #StructuralBiology

blog.matteoferla.com

Confabulating a crystal lattice

Matteo Ferla, a blog containing various tidbits of useful information, how-tos and what-ifs from biochemistry to Star Trek.

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Matteo Ferla @matteoferla.bsky.social · 29/04/2025

As my final task working in @opig.stats.ox.ac.uk & @cmd.ox.ac.uk I wrote a code-filled blogpost discussing what I did as a poweruser with RFdiffusion & co. to design inserts, linkers and more for specific problems to aid crystallography: www.blopig.com/blog/2025/04... 📚 #proteinengineering

blopig.com

AI generated linkers™: a tutorial | Oxford Protein Informatics Group

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Matteo Ferla @matteoferla.bsky.social · 20/02/2025

Why use a polyglycine linker in 2025?!

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Matteo Ferla @matteoferla.bsky.social · 26/01/2025

Some ideas are cool, but aren't easily doable, so I wrote a blog post about one: de novo binders that spontaneously form an irreversible isopeptide bond with their target protein www.blopig.com/blog/2025/01... —what's the catch? Many

de novo binder that forms an isopeptide bond

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Reposted by Matteo Ferla

Oxford Protein Informatics Group (OPIG) @opig.stats.ox.ac.uk · 15/01/2025

OPIG is now on Bluesky! Follow us for updates about the group's latest work, web app updates, and more. opig.stats.ox.ac.uk

opig.stats.ox.ac.uk

OPIG

Oxford Protein Informatics Group

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Matteo Ferla @matteoferla.bsky.social · 08/01/2025

There has been great discussions here about natural products for drug discovery. I want to add my take: the biosynthesis of these compounds often evolved as deterrents to kill us while our physiology evolved to fight them. blog.matteoferla.com/2025/01/natu... #chembio #chemsky

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Matteo Ferla @matteoferla.bsky.social · 19/12/2024

In an internal presentation today I had this comedy slide, which I am rather pleased with

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