Glad to share our work in Science Advances on how targeted cancer therapy promotes the persistence of topoisomerase 1 cleavage complexes, which are involved in the emergence of resistance in lung cancer. Many thanks to Olivier Sordet's lab and to all co-authors. www.science.org/doi/10.1126/...
science.org
Persistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targeted therapies in lung cancer
Resistance to targeted cancer therapies often arises from drug-tolerant cells, which survive treatment by entering a nonproliferative state. Over time, these cells can acquire mutations that contribut...
