Macrocyclic peptides present cyclic scaffolds, disulfide bonds and constrained arrangements, providing structural stability and diverse antimicrobial mecha

Macrocyclic peptides present cyclic scaffolds, disulfide bonds and constrained arrangements, providing structural stability and diverse antimicrobial mecha

This study examines how glyphosate, one of the most widely used herbicides worldwide, interacts with graphene-based materials. Using computer simulations,

Macrocyclic peptides present cyclic scaffolds, disulfide bonds and constrained arrangements, providing structural stability and diverse antimicrobial mecha

This study examined the folding of the C-terminal region of a liver fluke granulin and revealed distinct differences from the N-terminal region. Although t

This review highlights ribosomally synthesised and post-translationally modified peptides (RiPPs) from sponges and their microsymbionts. It covers sponge-d

The study described for the first time a new method for the synthesis of FeVI species under acidic conditions. Compared to alkaline methods, the advantages

Three new IrIII complexes were synthesised and characterised. The in vitro anticancer activity of the complexes toward SK-hep1 cells was explored upon irra

Bipyridine ligands with proximate H-bonding substituents in the 6,6′ positions have been used to prepare RuII complexes for potential application in the ho

Steel factories generate large amounts of waste rich in iron oxides, which can harm the environment. This study turned that waste into an eco-friendly magn

Lead contamination is prone to occur during the processing of high-salt foods. Conventional detection methods exhibit limited tolerance for high-salt matri

We show that chemical modifications of a thiophene moiety in ligand HS-276 can retain or disrupt its binding to Aβ deposits in Alzheimer’s disease. This fi

The n-octadecane reagent forms a stable water-in-oil emulsion with CNF. Formaldehyde reacts with melamine to produce melamine-formaldehyde resin prepolymer

Steel factories generate large amounts of waste rich in iron oxides, which can harm the environment. This study turned that waste into an eco-friendly magn

Disulfide-rich peptides are ultra-stable biomolecules, making them excellent candidates for drug development. This article explores their potential as prec

The potential of classical antimicrobial peptides in anti-virus therapy is discussed in light of research spanning decades. Neither the in vitro activity n

The potential of classical antimicrobial peptides in anti-virus therapy is discussed in light of research spanning decades. Neither the in vitro activity n

NMR spectroscopy helps analyse complex mixtures like cell culture media, revealing both expected and hidden components. It uncovered ethanol contamination,

DETA loading into MCM-48-C resulted in a more uniform distribution of DETA due to the presence of surfactant inside the carrier. Solid amine adsorbents ads

The solution structure and topology of a pH-sensitive, histidine-rich analogue of the antimicrobial peptide maculatin 1.1 were investigated using circular

Constrained peptides and compact proteins are exciting amino acid-based molecules with strong potential as new medicines. Smaller than antibodies, they can

ConnectSci

ConnectSci

By reaction of 5-methylisophthalaldehyde with 1,3-diaminopropane in the presence of various metal salts the following complexes have been isolated: MCu2Cl2,6H2O, MCu2(ClO4)2,2H2O, MCu2(HSO4)2,H2O, MNi...

A concise one-pot process for producing flavones and 2-alkyl-4H-benzopyran-4-one from a variety of salicylic acylbenzotriazoles is described. The in situ generation of o-(alkynon-1-yl)phenols in the i...

Australian Journal of Chemistry - an International Journal for Chemical Science publishes research papers from all fields of chemical science.

Waste coffee husks and spent coffee grounds (SCGs) are produced in large qualities worldwide. Characterisation of these waste streams from Australian commercial outlets in terms of lipid, caffeine, an...

N-methylation of cyclic peptides is a widely used strategy to enhance membrane permeability; however, it can also influence metabolic stability. In celebration of Professor David Craik’s scientific ac...

The endoplasmic reticulum (ER) is the most extensive organelle within eukaryotic cells and functions as a critical hub for cellular biosynthesis. It plays a pivotal role in protein biosynthesis and li...

Covalent chemical probes form a covalent bond with a target protein of interest to elicit an effect and methods to identify and characterise them are needed. We developed a native mass spectrometry (n...

A dibenzimidazolium salt based on binaphthol, 2,2′-bis[2′-(1-ethylbenzimidazole)ethoxy]-1,1′-binaphthol hexafluorophosphate (1) was synthesised. The recognition of compound (1) for Al3+ was studied by...

A symmetric tetramethylcucurbit[6]uril-based porous supramolecular assembly was prepared in an aqueous H2SO4 solution (5 M). The driving force for the formation of this assembly is mainly the outer su...

In this study, four DETA-SiO2 solid amine adsorbents were prepared by an impregnation method using diethylenetriamine (DETA) as the amine source and four types of silica with different pore structures...

An unusual triterpene fatty acid conjugate was isolated from the leaf resin of Dodonaea caespitosa. Its structure was formulated through spectroscopic analysis of the acetylated natural product and it...

Successful discovery of potent and selective ligands for therapeutically relevant receptors is indispensable for future clinical applications to treat a wide array of diseases. The mas-related G prote...

In the present study, a new type of material of Zr-TSCD was first synthesized and modified with different amounts of triethylenetetramine (TETA). The properties of the adsorbents were characterised wi...

Facile and concise procedures for the construction of indole fused N-heterocyclic systems were described. A series of benzo-, pyrido-, thieno-, naphtho-fused azepinoindolones and indolo-azepinoquinoli...

Acalypha indica is a herb that grows throughout the tropical regions of the world. As well as being exploited for medicinal use, the roots of this plant are known to elicit a drug-like effect in cats. Recent research into feral cat control on Christmas Island has investigated whether a preparation of the roots of A. indica might be effective in traps to attract feral cats. However, the volatile nature of the attractants made it unviable for use in traps for more than a few days. In this study, we investigated the volatile components emitted by the plant roots and identified two iridoid compounds, (4R,4aR,7S,7aR)-isodihydronepetalactone and (4R,4aS,7S,7aR)-isoiridomyrmecin, which are known to affect behavioural activity in cats. Synthesis of standards confirmed the stereochemistry of both compounds emitted by the plant. Potential application of these compounds in feral cat control is discussed.