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Masahiro Onji

@masaonj.bsky.social

159 followers 171 following 7 posts

Health sciences/Medical research/Stem-cell research

Posts Replies Media

Masahiro Onji @masaonj.bsky.social · 04/12/2024

Finally, thank you to the editor and referees for the constructive feedback.

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Masahiro Onji @masaonj.bsky.social · 04/12/2024

Whereas gut epithelial remodeling in pregnancy/lactation is reversible, constitutive activation of RANK drives intestinal expansion and prevents the formation of Apcmin-driven small intestinal stem cell tumors.

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Masahiro Onji @masaonj.bsky.social · 04/12/2024

Babies born to females that lack Rank in the intestinal epithelium show reduced weight and develop glucose intolerance upon metabolic stress.

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Masahiro Onji @masaonj.bsky.social · 04/12/2024

We found that RANK-RANKL signaling promotes the survival of the gut epithelia and controls the stem cell niche by increasing BMP receptor signaling, resulting in the elongation of villi.

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Masahiro Onji @masaonj.bsky.social · 04/12/2024

Receptor activator of nuclear factor kappa-Β (RANK) and its ligand RANKL were identified as a molecular pathway involved in this villous expansion of the small intestine in vivo in mice and intestinal murine and human organoids.

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Masahiro Onji @masaonj.bsky.social · 04/12/2024

We report that the intestinal epithelium expands during pregnancy and lactation in mice. This enlargement of the intestinal surface area is reorganized into sheet-like geometries.

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Masahiro Onji @masaonj.bsky.social · 04/12/2024

Excited to share my latest paper, published today at @natureportfolio.bsky.social ! A big thank you to all our collaborators. The paper shows how RANK drives intestinal epithelial expansion during reproduction. #intestine #stemcells #pregnancy www.nature.com/articles/s41...

nature.com

RANK drives structured intestinal epithelial expansion during pregnancy - Nature

The RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation.

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