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Mari de Sautu

@maridesautu.bsky.social

Postdoctoral fellow at Harvard Medical School (Harrison Lab). Studying viral cell entry by CryoET and CryoEM. Feminista, vegana, argentina 🇦🇷

Posts Replies Media

Mari de Sautu @maridesautu.bsky.social · 12/09/2026

Thank you, Nick!

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Mari de Sautu @maridesautu.bsky.social · 11/09/2026

I'm incredibly excited and honored that it was selected for the cover! 🎉 From day one, this tomography project has been an incredible journey. I feel deeply grateful to work with such an amazing team. A special thank you to Stephen Harrison, Simon Jenni, Conny Leistner, and Tom Kirchhausen.

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Mari de Sautu @maridesautu.bsky.social · 26/04/2026

My favorite thing to do during weekends 🙆🏽‍♀️🏕

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Mari de Sautu @maridesautu.bsky.social · 14/03/2026

Grant writing today with close supervision 😅

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Mari de Sautu @maridesautu.bsky.social · 14/03/2026

"Even in professional contexts, where there are power dynamics to contend with, it helps to “develop a sensitivity for who sees you as a human,” says Sehgal" Interesting reading for saturday morning. And friends makes us live longer, science showed. Used to be easier www.nytimes.com/article/how-...

nytimes.com

How to Make Friends as an Adult

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Mari de Sautu @maridesautu.bsky.social · 26/02/2026

I’m deeply grateful to everyone involved in this work, and especially to my great friend and supervisor @irenemangialavori.bsky.social for her guidance and support throughout this project. (4/4)

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Mari de Sautu @maridesautu.bsky.social · 26/02/2026

In some lipid environments, inhibition is strong; in others, it is reduced or even reversed. These findings highlight how membrane composition can fine-tune the regulation of a critical calcium pump and the importance of protein–lipid interactions in controlling membrane protein function. (3/4)

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Mari de Sautu @maridesautu.bsky.social · 26/02/2026

We explored how the lipid environment surrounding PMCA modulates its inhibition by aluminum. Using biophysical approaches including small-angle X-ray scattering, fluorescence probes, and activity assays, we found that aluminum’s impact on PMCA is highly dependent on membrane context. (2/4)

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Mari de Sautu @maridesautu.bsky.social · 26/02/2026

I’m excited to share another publication from my PhD: authors.elsevier.com/a/1meGTWFfh2... The plasma membrane Ca²⁺-ATPase (PMCA) is a key enzyme responsible for maintaining intracellular calcium homeostasis by actively extruding Ca²⁺ from the cell. (1/4)

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Mari de Sautu @maridesautu.bsky.social · 27/01/2026

Dissociated VP7 monomers form a single, large, cooperative pore, seen both in cells and in liposomes. An amphipathic VP7 helix is sufficient for perforation, enabling rapid DLP release and immediate viral transcription in the cytosol (3/3).

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Mari de Sautu @maridesautu.bsky.social · 27/01/2026

We show that entry is a two-step membrane insertion process. VP4 spikes switch from upright (attachment) to reversed (insertion of foot domain). This triggers Ca²⁺ leakage from vesicle, Ca2+ signaling and ultimately VP7 dissociation (2/3)

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Mari de Sautu @maridesautu.bsky.social · 27/01/2026

Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.6...

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