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Marianne Bauer

@mariannebauer.bsky.social
166 followers 163 following 16 posts

Theoretical Biophysicist @ TUDelft, previously Princeton, Munich, Cambridge. sites.google.com/view/bauergroup/ho…

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Marianne Bauer @mariannebauer.bsky.social · 20/03/2026
Our paper on inferring Wnt signals just got published with PRR! doi.org/10.1103/f7qj...
 We use ideas from efficient coding to infer the best possible set of Wnt signals for cells to respond to: these signals are discrete, and do not need to be fine-tuned. (1/n)
doi.org
Optimizing information transmission in optogenetic Wnt signaling
Populations of cells regulate gene expression in response to external signals, but their ability to make reliable collective decisions is limited by both intrinsic noise in molecular signaling and var...
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Marianne Bauer @mariannebauer.bsky.social · 30/01/2026
In a really fun collaboration with Max Wilson’s lab at UCSB, we’ve developed a simple model that can capture the non-monotonic expression of Wnt target genes with respect to frequency in periodic (optogenetic) Wnt pulses: elifesciences.org/articles/107.... Great work Sam, Olivier, Naomi and Ryan :)
elifesciences.org
Anti-resonance in developmental signaling regulates cell fate decisions
Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer spec...
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Marianne Bauer @mariannebauer.bsky.social · 09/01/2026
The first paper from my group just got published: doi.org/10.1103/cx3r... Local clustering of transcription factors at binding sites can be beneficial for information transfer -- a relief for taking infomax ideas seriously :) And it helps the binding sites achieve a sweet spot in the IB plane.
doi.org
Weak Transcription Factor Clustering at Binding Sites can Facilitate Information Transfer from Molecular Signals
By analyzing bicoid regulation in the fruit fly embryo, this study shows that weak clustering of transcription factors can enable maximal transfer of information from molecular signals to downstream g...
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Marianne Bauer @mariannebauer.bsky.social · 03/02/2025
Impressive paper from the Tanenbaum lab - high-resolution imaging on individual and small numbers of ribosomes on socRNAs to see how ribosomes move.
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