iiinova — where your digital self keeps evolving

Dr. María D. Mayán @mariamayan.bsky.social · 25/09/2026

No os perdáis las actividades de esta tarde noche en #Vigo Esta mañana en Redeiras hablando con 💙🔬🧬 @cinbio.bsky.social Esta tarde estaré en la Biblioteca Pública Municipal Xosé Neira Vilas de Vigo - 19.30 h

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Dr. María D. Mayán @mariamayan.bsky.social · 29/07/2026

Finished #IGJC2026 in Padua 🇮🇹Always a pleasure to reconnect with the amazing connexin & pannexin community. Proud of Soumo (&Alex) for their oral presentation, and honoured to give a keynote on our 15-year journey studying connexins in aging and cancer. 🙌🏻 See you in Mexico 🇲🇽!

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Dr. María D. Mayán @mariamayan.bsky.social · 21/07/2026

Finishing the #9AMCINBIO with great talks. Not everyone is in the photo, but our group wishes you all a wonderful summer! A special mention to Paula Carpintero, a former CellCOM member, who came back home to participate in a round table Have a great summer! ☀️🔬 @cinbio.bsky.social

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Dr. María D. Mayán @mariamayan.bsky.social · 13/07/2026

Muchas gracias @gciencia.bsky.social por hacerse eco de nuestro proyecto y a #Gain por su apoyo con #ignicia que cuenta con grandes profesionales con vocación de mejorar el ecosistema biotech. Ojalá formemos parte de sus éxitos, pondremos todas nuestras energías en ello! 🔬💊

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Dr. María D. Mayán @mariamayan.bsky.social · 09/06/2026

Muy agradecida y emocionada de recibir la #BecaFERO en cáncer de mama de la @fundacionfero.bsky.social con el apoyo de #GHD para desarrollar nuestro proyecto en cáncer de mama🩷Muchas gracias al comité científico de #FERO por su confianza y apoyo💙Emocionada! @cinbio.bsky.social @uvigo.bsky.social

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Dr. María D. Mayán @mariamayan.bsky.social · 08/05/2026

Un placer y muy agradecida de formar parte de esta iniciativa de la Universidad de Vigo para fomentar vocaciones científicas en el ámbito STEM👇🏼

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Dr. María D. Mayán @mariamayan.bsky.social · 10/02/2026

Qué mejor forma de empezar a celebrar el #11F q acompañada por Ana María Rocha, radióloga de la Unidad de Mama del H. Álvaro Cunqueiro, en el Colegio Rosalía de Castro, rodeadas de mentes curiosas y futuras científicas 💜🔬👩‍🔬 #Conócelas @aseica.bsky.social @cinbio.bsky.social @uvigo.bsky.social

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Dr. María D. Mayán @mariamayan.bsky.social · 30/12/2025

A few days before finishing this year, I want to thank all the wonderful people who surrounded and supported us during 2025 💙 It was a great year, full of new results, projects, recognitions, and collaborations. Thanks to all of you, More to come in 2026!🚀👩‍🔬🧑‍🔬 @cinbio.bsky.social @uvigo.bsky.social

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Dr. María D. Mayán @mariamayan.bsky.social · 27/09/2025

Mural #MulleresNaCiencia de Expostas en #Vigo con @msmelanoma.bsky.social Mujeres brillantes, valientes, resilentes, líderes e inspiradoras 💜

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Dr. María D. Mayán @mariamayan.bsky.social · 28/07/2025

🧠 We show for the first time that (1) Cx43–lamin interaction alters DNA repair pathway choice, boosting therapy, preventing resistance, and resensitizing resistant tumours, and (2) we have developed a smart strategy to deliver Cx43 mRNA to tumours🚀 This is our model👇

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Dr. María D. Mayán @mariamayan.bsky.social · 28/07/2025

💊 Restoring Cx43 in tumour cells has been challenging. After testing multiple strategies, extracellular vesicles (EVs) proved most effective, delivering both Cx43 protein (via their membranes) and Cx43 mRNA, by engineering the EV-producing cells

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Dr. María D. Mayán @mariamayan.bsky.social · 28/07/2025

🎯 Most importantly, restoring Cx43 avoided drug resistance in vitro and prevented resistance in vivo. Even better, drug-resistant cells, which are more vulnerable to DNA damage, became more sensitive to Cx43 restoration 💪

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Dr. María D. Mayán @mariamayan.bsky.social · 28/07/2025

🧬Thanks to @Gsabiolab @DNA_Repair_USC & @PabloHuertasLab we found that this interaction recruits DNA damage foci to the nuclear membrane, restricting HR & promoting error-prone repair driving genomic instability, which is further enhanced by DNA-damaging drugs like BRAF/MEKi💥

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Dr. María D. Mayán @mariamayan.bsky.social · 28/07/2025

🔍 What did we find? Surprisingly, Cx43 antitumour effects in BRAF- (and NRAS)-mutant tumours do not seem to rely on its channel activity. Instead, we found Cx43 localizes to the nucleus and strongly interacts with nuclear lamin and DNA repair proteins⚙️

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Dr. María D. Mayán @mariamayan.bsky.social · 28/07/2025

💭Cx43 shows antitumour activity in many cancers, but the mechanism remained controversial. We hypothesized that restoring Cx43 could help the microenvironment suppress growth and boost therapy response via its channel activity; a “kiss of death”

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Dr. María D. Mayán @mariamayan.bsky.social · 28/07/2025

💥Check out our latest work in @NatureComms We identify a new target to impair DNA repair🧬inducing #senescence and #celldeath through synthetic lethality in combination with cancer therapy🧵 🔗Open access PDF: rdcu.be/euQkW

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Dr. María D. Mayán @mariamayan.bsky.social · 09/07/2025

Today is the last day of Jolita and Tomas from @IMCentras in the lab! It has been a pleasure to host them these last weeks through @Everest_MSCA They will still join the CINBIO Annual Meeting at @MuseoMARCO tomorrow. Great talks and speakers ahead! ✨

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