iiinova — where your digital self keeps evolving

War and peace is very secondary to making money US, Russia explore gas sale to Europe amid Ukraine war, say sources www.reuters.com/busi... 1/3

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Beyond genes: EpiSwitch® and Orion platform-powered 3D genome architecture biomarkers reveal shared biology across ME/CFS, long COVID, PTSD, rheumatoid arthritis, and multiple sclerosis

Beyond genes: EpiSwitch® and Orion platform-powered 3D genome architecture biomarkers reveal shared biology across ME/CFS, long COVID, PTSD, rheumatoid arthritis, and multiple sclerosis Hypothesis-generating, not strong evidence of shared mechanisms. link.springer.com/ar... 1/6

link.springer.com

Journal of Translational Medicine - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long COVID (LC19), post-traumatic stress disorder (PTSD), rheumatoid arthritis (RA), and multiple...

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Marc Veldhoen @marcveld.bsky.social · 13h

They will never stop propagating the same false claim, waylaid many times and derived from not even reading the study referred to, will they?

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Marc Veldhoen @marcveld.bsky.social · 8h

Trump backs away from top aides who reportedly advised pro-Russia government President floats firing Chris LaCivita and James Blair over any ‘conflict’ after reports of work in Republika Srpska

theguardian.com

Trump backs away from top aides who reportedly advised pro-Russia government

President floats firing Chris LaCivita and James Blair over any ‘conflict’ after reports of work in Republika Srpska

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EFIS_Immunology @efis-immunology.bsky.social · 06/10/2026

🔬T-cell Connect Europe (TCCE), the EFIS–Immunology Letters study group, initiated the series focusing on #Tcellbiology + T cell-mediated immunity in 2020 in response to the pandemic to facilitate exchange among T-cell immunologists. 💡Monthly every 1st Tuesday at 17:00, for two talks + discussion.

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Marc Veldhoen @marcveld.bsky.social · 13h

They will never stop propagating the same false claim, waylaid many times and derived from not even reading the study referred to, will they?

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Simon Marks @simonmarksfsn.bsky.social · 15h

Meanwhile, the White House is convulsed by the revelation that two Trump political advisors, supposedly overseeing the Republican midterm campaign, were instead moonlighting to help pro-Russian politicians in the Balkans. In both cases, the taint is indelible. www.politico.com/newsletters/...

politico.com

Knives out for Blair and LaCivita

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Simon Marks @simonmarksfsn.bsky.social · 15h

Two extraordinary stories today alleging fresh corruption in Trump's ranks. On the very day Rubio, at the Acropolis, sought to kick-start his presidential campaign, the US Ambassador to Greece is in deep manure.... 1/2 www.wsj.com/politics/pol...

wsj.com

Exclusive | ‘Honey Please’: Kimberly Guilfoyle Pushed Donor to Wire $100,000 to Her Amex Account

Text messages with a MAGA ally show Guilfoyle seeking funds and offering access to top administration officials before becoming ambassador to Greece.

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This paper is not evidence that LC and ME/CFS have a shared cause; no diagnostic biomarker has been validated, and no therapeutic target has been identified. It only suggests both diseases occupy overlapping regions of immune-metabolic space in this computational framework. 6/6

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Pathway enrichment and network biology studies in general have known limitations. Different gene sets can map onto the same large immune/metabolic network even when the underlying biology is not truly shared. 5/6

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The idea that chronic inflammatory diseases converge on immune/metabolic stress pathways is biologically plausible. Common hubs are present in many chronic diseases. Finding them does not necessarily reveal a specific disease mechanism. 4/6

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A lot of convergence on immune/cytokine signalling, mitochondrial biology, metabolism and neuroendocrine signalling is claimed, but there is limited overlap in the actual genes identified in each disease. The authors do not claim that the diseases are identical. 3/6

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EpiSwitch 3D genomics platform and the Orion knowledge base are used to integrate existing genomic datasets from ME/CFS, LC, PTSD, RA, and MS. Then, a network analysis is performed (STRING/Cytoscape) to look for convergence on common biological pathways 2/6

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Wanneer je niet begrijpt wat "gain of function" is. Er zijn zeer goede redenen om met de bacterie Yersinia pestis te werken, zoals het ontwikkelen van verbeterde diagnose- en behandelingsmethoden. Dat heeft helemaal niets met GoF te maken. Dit is wederom click-bait.

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Any of this is unlikely to happen. But Putin dangles a carrot in front of non-diplomats in increasingly larger proportions to continue his war and gain time. No actual transactions have taken place. 3/3

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Top Russian and US officials, including US Special Envoy Jared Kushner, have held talks about bringing a US investor into the Nord Stream pipelines that delivered gas to Germany before Russia invaded Ukraine, five people with knowledge of the situation said. 2/3

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War and peace is very secondary to making money US, Russia explore gas sale to Europe amid Ukraine war, say sources www.reuters.com/busi... 1/3

121

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Marc Veldhoen @marcveld.bsky.social · 19h

Week 40, the official start of the new virus season. Not much to see, but pay attention to the very start of the graphs; it is the red dot that provides the current detected levels in the Netherlands. RSV and Influenza A (and B) viruses are still very low. 1/2

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Digging a bit deeper; the single patient reporting initial improvement (which had to be stopped due to side effecct and compensatory mechanisms kicking in) was also an author on the study. GWAS studies with ME/CFS or LC did not identify rs5522. If it was that important, it would have been.

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Marc Veldhoen @marcveld.bsky.social · 20h

Much is worth exploring. But there is very little evidence for this. A case report of one homozygous patient. There is no reported genetic link with this receptor, there are no clinical trials or other strong data It's potential importance is hugely overstated in light of this.

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sequences of a potential pathogen likely causal of the death. It is very rare this is not identified nowadays. But even tests being performed seem to be kept secret, let alone the resulting data. Stick to the facts, don't speculate for clicks.

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If this is plague, it can be treated very well with antibiotics. There are regular outbreaks annually (~2000 deaths), and that is not an pandemic risk. Unfortunately there is no information on antibiotic use. The sad death of at least one person should have resulted in

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🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️

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SARS-CoV-2 mRNA levels in wastewater have been rising slowly, but have not reached levels of previous years. A downward trend may set in soon if it follows a pattern similar to the previous two years. Very few people report an infection with SC2. 2/2

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Kai Kupferschmidt @kakape.bsky.social · 07/10/2026

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Reposted by Marc Veldhoen

"Information from Russia has been incomplete, confusing, and contradictory." My colleague @martinenserink.bsky.social on what we know so far about the possible plague death in Russia and the implications. 🧪

science.org

Possible plague death at a Siberian lab baffles scientists

Much is unclear about the tragedy, but plague researchers say there is “zero” chance of an epidemic

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Prof Sheena Cruickshank @sheencr.bsky.social · 07/10/2026

Last year RFKJr and Trumps made wild claims about Tylenol and the risk in pregnancy of children developing autism that were not backed up by science in any way. This led to a drop in its use as women became anxious about risking their baby. Now researchers have looked at social media influence

cidrap.umn.edu

Tylenol use in pregnant women visiting ED dropped after Trump’s unfounded autism claim

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This is the first time the United States has declined to invite in OSCE monitors since they began observing US elections. The Trump administration’s decision “represents a significant departure from an established democratic practice.”

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Reposted by Marc Veldhoen

Pennsylvania’s measles outbreak is the largest in decades in the US

Pennsylvania’s measles outbreak is the largest in decades in the US With nearly 3,900 reported cases, the nation is enduring its worst year for measles since 1991, according to the CDC.

politico.com

With nearly 3,900 reported cases, the nation is enduring its worst year for measles since 1991, according to the CDC.

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Caught COVID shortly after vaccination? That happens, and immunology predicts it. Protection is not instantaneous. People infected just before or after vaccination can develop symptoms before vaccine-induced immunity has had time to develop. That's biology. 1/2

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marcveldhoen.substack.com

The claim that CDC "hid" these infections misunderstands how they work. You cannot measure protection before it exists. The 14-day window is a standard epidemiological approach. Multiple studies found strong protection against severe COVID-19. marcveldhoen.substac... 2/2

Caught Covid soon after your jab?

This is something that keeps circulating from soon after the COVID-19 vaccinations started.

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Quarantine measures have been put in place after a female researcher at an anti-plague institute died of "pneumonia of unknown" origin. Russian authorities have not confirmed her exact cause of death. 2/2

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It is now suggested that this was not a case of plague, according to WHO. US 'closely monitoring' after Russian laboratory worker 'dies of suspected pneumonic plague' news.sky.com/story/r... 1/2

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These type of viruses are very fast and your immune system is hard at work: that causes the feeling of being ill and the "flu-like" symptoms.

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Indeed, Ivermectin doesn't work. But the claim that SARS-COV-2 infection doesn't give you long-lasting immunity is also wrong. You will select and store many B and T cells directed against conserved virus parts. You will activate these after reinfection.

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The bans involved a “record number of unique titles” – exceeding 7,000 – involving more than 4,000 authors, illustrators and translators. Analysts found 114 school districts that banned books during the school year, “the highest number ever for a single year”.

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US book bans in public schools reach record annual high of 12,000

Because .... FREEDOM US book bans in public schools reach record annual high of 12,000 Texas tops list with 8,100 bans while Stephen King is again most banned author, PEN America finds

theguardian.com

Texas tops list with 8,100 bans while Stephen King is again most banned author, PEN America finds

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Health experts attribute such outbreaks to low vaccination rates. MAHA

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