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Marco Malatesta

@marcomala46.bsky.social

Marco Malatesta @marcomala46.bsky.social · 17/07/2026

🚀 Excited to share our latest work on bioRxiv! We identify L2HGDH as an integral component of the COQ metabolon, physically interacting with the complex and fueling coenzyme Q biosynthesis by reducing quinone intermediates. #bioRxiv #CoQ #Mitochondria #StructuralBiology #Metabolism #CryoEM

biorxiv.org

L-2-hydroxyglutarate recycling is linked to coenzyme Q biosynthesis

The mitochondrial COQ metabolon catalyzes the late stages of the biosynthesis of coenzyme Q, an essential and ubiquitous cofactor. Here, by integrating coevolution, coexpression, colocalization and do...

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Reposted by Marco Malatesta

SIB Swiss Institute of Bioinformatics @sib.swiss · 09/09/2025

We ended the first day with an address from Dr. Lukas Engelberger, Head of the Department of Health of Kanton Basel-Stadt who welcomed us in Basel; and with an apero and dinner. #bc2basel

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Reposted by Marco Malatesta

Riccardo Percudani @percud.bsky.social · 01/08/2025

We used coevolutionary analysis of KEGG networks to identify the gene linked to L-xylulose formation in human metabolism and Garrod's pentosuria. #Bioinformatics #Genomics #Biochemistry Now in PNAS: t.co/iPIhrbUmxz (Preprint: www.researchsquare.com/article/rs-6...)

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