Reposted by @mar-ferrando-marco.bsky.social
Proud to have contributed to this work! We built a stochastic agent-based model, revealing that axonal injury promotes retention in white matter leading to dense wild-type tumours, while absence of axonal injury leads to disseminated tumours and delayed glioblastoma progression.
![figure 3 (C) Representative images of LIT-1::GFP following the L2 asymmetric division in controls (WT), tissue-specific efl-3 mutants [efl-3(−)] and animals containing the lit-1(icb164) CRISPR deletion. Seam cell nuclei are circled in white. Hypodermal nuclei are labelled with blue arrowheads. a, anterior daughter cell; p, posterior daughter cell.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:btitwyhiegkb6f62oguxt6m6/bafkreih2xjdz4bhvm7z7h5d7i3gx4qw2xrfhix3iphhvaddvhaogimnz4y)