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Mandala Lab

@mandala-lab.bsky.social

105 followers 221 following 3 posts

Molecular & Membrane Biophysics Dept. of Biochem. & Mol. Biol. Carver College of Medicine bmb.medicine.uiowa.edu/profile/venk… scholar.google.com/citations?user=2…

Posts Replies Media

Reposted by Mandala Lab

Chen Zhao @chen-zhao.bsky.social · 22/03/2026

Our first paper is finally online. Congratulations to the team for the effort! Hopefully a high-resolution structure in the transmembrane domain will be resolved in the future.

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Mandala Lab @mandala-lab.bsky.social · 15/11/2025

Read our work on protein-rich domains in the plasma membrane: www.biorxiv.org/content/10.1...

biorxiv.org

Spatial deconstruction of the plasma membrane

The plasma membrane of cells is known to be heterogeneous with regards to the spatial distribution of proteins and lipids. The segregation of molecular species in the cell membrane into specific domai...

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Reposted by Mandala Lab

George Vaisey @gvaisey.bsky.social · 25/10/2025

Happy to share our latest work on Piezo: www.biorxiv.org/content/10.1...

biorxiv.org

Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating

Piezo1 ion channels are widely expressed cellular mechanosensors. They adopt an intrinsically curved shape when closed and are thought to open when mechanical forces applied to the membrane favor a mo...

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Reposted by Mandala Lab

The Rockefeller University @rockefeller.edu · 09/07/2025

A @pnas.org study from the MacKinnon lab finds that proteins contact each other in a variety of ways to form self-clusters, highlighting the diversity of chemical interactions nature uses in the formation of protein assemblies in cell membranes.

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Mandala Lab @mandala-lab.bsky.social · 14/05/2025

Our ability to send electrical signals rapidly to distant parts of the body depends on membrane proteins called voltage-dependent ion channels. These channels have voltage sensing domains that sense the voltage difference across the cell membrane and open or close the channel accordingly.

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