Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 29/09/2026After another exciting year of research collaboration, it’s time for the #WORMVACS annual meeting – this time in Barcelona! 🙌 Learn about recent updates in our efforts to develop a #helminth vaccine ➡️ wormvacs.org/news #HaDEA @ec.europa.eu 020
Reposted by Malaria Immunology Lab at ISGlobalLINQ management GmbH @linq-management.bsky.social · 25/09/2026What is the difference between developing vaccines against viruses and worms? Rebeca Santano (@malaria-immuno.bsky.social) explains the science behind #ParasiticWorms vaccines➡️ tinyurl.com/mr4asr5c #EuropeanResearchersNight #NitEuropeaDeLaRecerca #BeatNTDs #WORMVACS #HaDEAtinyurl.comThe COVID-19 vaccine was developed in less than a year.La investigadora Rebeca Santano ens presenta la seva recerca sobre les vacunes en aquesta micoxerrada: The COVID-19 vaccine was developed in less than a year. Why are we still waiting for a vaccines against worms? 031
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 20/07/20269/ ➡️ The takeaway: malaria coinfection reshapes both the inflammatory and the antibody response to helminths. This could have consequences for worm expulsion and parasite survival, and is an important consideration for the design and evaluation of helminth vaccines. 000
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 20/07/20268/ ➡️ Several antigens (Sh-SERPIN, Sm-SERPIN, As-37, Na-SAA-2, Na-GST-1 and Tm-16) were consistently boosted across multiple isotypes: IgG, cytophilic IgG subclasses, IgM and IgE. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 20/07/20267/ ➡️ Helminth-specific antibody responses were significantly enhanced in coinfected children, with total IgG and IgM showing the strongest associations. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 20/07/20266/ ➡️ Malaria coinfection amplified inflammation, with raised pro-inflammatory cytokines (IL-2R, IL-6), cell-recruiting chemokines (MCP-1, MIG), anti-inflammatory proteins (IL-1RA, IL-10) and the growth factor HGF. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 20/07/20265/ ➡️ Coinfected children had a higher prevalence of anaemia than those with helminths alone (33%, p = 0.006). 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 20/07/20264/ In plasma we measured 30 cytokines, chemokines and growth factors, total IgE, and helminth-specific IgM, IgA, IgG, IgG1–4 and IgE antibodies against 11 helminth antigens by Luminex. What we found: 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 20/07/20263/ To explore this, we studied a cohort of 441 children aged 2–10 recruited from two hospitals in the Manhiça District (Southern Mozambique). Among them, 96 carried helminth infections, and 16 (17%) of those were also infected with Plasmodium falciparum. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 20/07/20262/ Helminths and malaria overlap across much of the tropics, so coinfections are common. Plenty of work has asked how worm infections shape malaria immunity, but the reverse question has been largely overlooked: what does a malaria coinfection do to the immune response against the worms themselves? 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 20/07/20261/ 📣 New paper alert! "Helminth-infected Mozambican children with malaria have increased anaemia, cytokines and helminth-specific antibodies" Explore the graphical abstract below 👇 🔗And read the full paper here:https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0014485 110
Reposted by Malaria Immunology Lab at ISGlobalBritish Society for Immunology @britsocimm.bsky.social · 02/07/2026Talking about vaccines can feel challenging, but clear, trusted conversations make a difference. Our free toolkit and Top Tips poster support researchers and communicators to plan, deliver and reflect on effective engagement. Explore our tips: vist.ly/59tbs 054
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 03/07/20269/ 👏 Huge congratulations to all the authors and teams involved, with special mention to our partners at IDIAP Jordi Gol and the Institut Català de la Salut, as part of END-VOC! 000
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 03/07/20268/ ➡️ The takeaway: for long-term protection, antibody quality may matter as much as quantity. This is a key consideration for designing future boosters, which remain essential against emerging variants. 110
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 03/07/20267/ ➡️ But not all antibodies protect equally. During Omicron circulation, higher IgG2 and IgG4 were linked to greater risk of breakthrough infection, while IgG1 and FcγR- and C1q-binding antibodies were associated with protection. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 03/07/20266/ ➡️ The subclasses appear to compete: IgG4 correlated with FcγR- and C1q-binding (functional) antibodies only in participants with lower IgG1, pointing to competition between subclasses. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 03/07/20265/ ➡️ IgG2 and IgG4 persist longer in circulation than IgG1, and IgG4 recognised a broader range of Omicron variants. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 03/07/20264/ ➡️ Your first encounter with the virus leaves a lasting imprint. People infected before vaccination developed less IgG2 and IgG4 than those vaccinated first and infected later. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 03/07/20263/ To help shed light on this, we followed a well-characterised cohort of 93 healthcare workers recruited in the earliest days of the pandemic in Central Catalonia (Spain), measuring IgG1–IgG4 against multiple SARS-CoV-2 variants, alongside FcγR- and C1q-binding antibodies. What we found: 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 03/07/20262/mRNA vaccines have saved millions of lives. But we and others had noticed that repeated vaccination triggers an unusual shift in antibody subclasses, with rising IgG2 and IgG4; a phenomenon whose biological basis remains incompletely understood. 110
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 03/07/20261/ 📣 New paper alert! "First exposure to SARS-CoV-2 shapes IgG subclass switching after mRNA vaccination" Explore the graphical abstract below 👇 🔗And read the full paper here: www.nature.com/articles/s43... 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 19/06/20262/2 🟨 Method Spotlight from the Malaria Immunology Lab 🟨 000
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 19/06/20261/2 🟨 Method Spotlight from the Malaria Immunology Lab 🟨 500 analytes, one drop. We use Luminex xMAP every day to measure antibodies against malaria, vaccines like RTS,S and more, from a single drop of plasma, serum or saliva. See how it works in the images 👇 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 15/06/2026🇳🇱➡️🇪🇸 From the Netherlands to Spain: a laboratory knowledge exchange. Great to welcome Geartsje Bakker (Wageningen University) to our lab for hands-on training and protocol sharing within #WORMVACS. Thanks for the visit! Read more 👇 www.wormvacs.org/news/blog/ne...wormvacs.orgFrom the Netherlands to Spain: a laboratory knowledge exchange — WORMVACS2.0PhD candidate Geartsje Bakker from Wageningen University travelled to ISGlobal in Spain for a study visit, during which she learned to use the local team’s Luminex technique and tested her plant-produ... 011
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 10/06/2026🟦 Science Bites 🟦 🦟💉 What is the RTS,S malaria vaccine and why does our lab study it? We have put together our first #ScienceBites, a series where we break down the science behind our research into digestible bites to make it more accessible. Swipe through to learn more! 👉 001
Reposted by Malaria Immunology Lab at ISGlobalLINQ management GmbH @linq-management.bsky.social · 02/06/2026🪱Are you a researcher interested in parasitic worm infections? 📱The #WORMVACS team has set up a data warehouse that stores clinical trial, experimental, and analysis data from studies concerning #hookworm & #SchistosomaMansoni. Learn how to find the data you need➡️ youtu.be/G7wsNZvpGJIyoutu.beHow to find data from parasitic worm infection studies | WORMVACS2.0YouTube video by LINQ management 011
Reposted by Malaria Immunology Lab at ISGlobalParc Científic de Barcelona @www.pcb.ub.edu · 02/06/2026#PCBCommunity |🎬 Al #CoffeeConnection, vam conversar amb la Ruth Aguilar, staff scientist de @malaria-immuno.bsky.social, per conèixer de prop l’estudi de biomarcadors i de les respostes immunes amb tecnologies que permeten tenir amb volums de mostra molt petits i generar dades d’alta qualitat. ▶️👇youtu.beCoffee Connection: Entrevista a Ruth Aguilar, Staff Scientist a ISGlobalYouTube video by Parc Científic de Barcelona 011
Reposted by Malaria Immunology Lab at ISGlobalParc Científic de Barcelona @www.pcb.ub.edu · 15/05/2026#PCBCommunity |🔬 Investigadores de @malaria-immuno.bsky.social demostra que potenciar els anticossos dirigits a la regió C-terminal de la proteïna del paràsit millora l’eficàcia de la vacuna RTS,S contra la #malària a partir dels resultats d'un assaig clínic Fase 3 a l’Àfrica subsahariana. 🦟🌍pcb.ub.eduUn estudi liderat per l’ISGlobal aporta noves evidències sobre la durada dels anticossos per millorar la vacuna RTS,S contra la malària - Parc Científic de BarcelonaEl treball, dut a terme en el marc d’un assaig clínic de fase 3 de la vacuna RTS,S en diversos països de l’Àfrica subsahariana, s’ha publicat a The Lancet Infectious Diseases. 011
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 24/04/2026🪱Around the world, people continue to suffer from the effects of #ParasiticWorm infections. 💉Explore the three innovative vaccine production platforms used by #WORMVACS researchers aiming to establish an effective parasitic worm vaccine pipeline➡️ tinyurl.com/ydpenjda #WorldImmunisationWeektinyurl.comInnovation in parasitic worm vaccine research: platforms used in WORMVACS2.0 — WORMVACS2.0Explore the three innovative vaccine production platforms used by WORMVACS2.0 that have not yet been applied in worm vaccine development: mRNA, outer membrane vesicles, and recombinant glycoproteins p... 000
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 23/04/2026New paper out! 🙌 We investigated the durability and protective role of IgG to CSP C-terminus and NANP-repeat antigens following RTS,S/AS01E vaccination in young African children. Read the full paper here ➡️ doi.org/10.1016/S147... Congratulations to all the people involved! 👏 000
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 22/04/2026📣 Open Postdoc Position in Humoral Immunity | Malaria Immunology Group @ISGlobal – Barcelona B-cell biology • monoclonal antibodies • RTS,S vaccine immunology Marie Curie IF or equivalent. PhD in immunology required. 👉 jobs.isglobal.org/jobs/7606758 #Immunology #Malaria #Postdoc #ScienceJobsjobs.isglobal.orgInvitation to apply for a post-doctoral position in Humoral Immunity - Barcelona Institute for Global Health (ISGlobal)The Barcelona Institute for Global Health (ISGlobal) is a cutting-edge institute addressing global public health challenges through research, translation into policy and education. ISGlobal has a b... 020
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 14/04/2026📣 Exciting news for the parasitology community! Carlota Dobaño, PI of our group, has been appointed co-Editor in Chief of npj Parasitology, a new open access journal that will publish high-quality research across parasitology. Submissions are now open 👇 www.nature.com/npjparasitol... 010
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 10/04/2026New paper out! 🙌 We explored how helminth coinfections affect clinical, parasitological, and immune outcomes in Mozambican children with P. falciparum malaria. Read more here ➡️ rdcu.be/fcJGR Congratulations to all the people involved 👏 010
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 11/02/2026Today, on the ✨ International Day of Women and Girls in Science ✨ , we celebrate the little girls behind the scientists we are today. May every girl find representation in today's world and feel that science is a place where she belongs and where her curiosity can grow into discovery. 020
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 30/01/2026Today is the World NTD day! 👩🏾⚕️ Who are the people looking for new vaccines against #NeglectedTropicalDiseases such as parasitic worm infections? 🏥 Meet the team at CERMEL, one of the #WORMVACS partners➡️ youtu.be/4Ver6pTdWgY @ec.europa.eu #HaDEA #BeatNTDs #schistosomiasis #worldNTDdayyoutu.beThe people behind new vaccines for neglected tropical diseases: World NTD Day 2026 | WORMVACS2.0YouTube video by LINQ management 010
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 28/01/2026We have a new paper out in BMC Medicine on long-term immune responses to SARS-CoV-2 in asymptomatic-to-moderate COVID-19 cases from sub-Saharan Africa. Check the full publication here 👉 link.springer.com/article/10.1... Congratulations to all the people and teams involved! 👏 000
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 18/12/2025Today in the lab we had an early Caga Tió surprise 🎁 Before heading off for the Christmas holidays, we celebrated together with a small get-together and shared some delicious panettone. From the Malaria Immunology Lab we wish everyone a restful break and happy holidays! 🎄 020
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 12/12/2025This week we are sharing a video where our group leaders, Carlota Dobaño and @moncunill.bsky.social, explain our research on immune responses, vaccines and longterm impact of infections. It was filmed in our new lab space at the Barcelona Science Park, where we moved this September. 022
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 28/11/20255/ Congratulations to both Marloes and Jeremia on their outstanding work, and thank you to LUMC for such a memorable academic tradition! 👏 010
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 28/11/20254/ Both of them were under the supervision of Prof. Dr. Maria Yazdanbakhsh. The ceremonies took place at the beautiful Academiegebouw in Leiden, a place that impressed our team, but not as much as the scientific excellence of the candidates! 😊 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 28/11/20253/ Carlota Dobaño was part of the opposition committee for Jeremia Pyuza, defending his thesis “The immune divide: factors influencing immune variation and differences in vaccine response.” 110
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 28/11/20252/ @moncunill.bsky.social served as an opponent for the defense of Marloes van Dorst, presenting her thesis “Overlapping patterns and unique differences: A study into immunological variation within and between populations.” 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 28/11/20251/ This week our research group made an important discovery: scientists look fantastic in Dutch academic togas 🎓✨ Our two PIs went to Leiden to take part in not one, but two PhD thesis defenses! This experience was filled with rich scientific discussions… and a definite Hogwarts-like atmosphere. 121
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 27/11/2025Check out the infographic we prepared and visit the project website to learn more about this exciting work lead by Ron Hokke and his team at LUMC and with collaborations with all the partners you see in the infographic! ➡️ www.wormvacs.org 010
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 27/11/20258/ Our contribution to WORMVACS2.0 focuses on closing critical knowledge gaps in human immunology to ultimately support the development of vaccines 💉 against two major helminths: Necator americanus and Schistosoma mansoni. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 27/11/20257/ His presentation set the stage for introducing the optimization of a Luminex panel to measure antibody levels and antibody functionality for helminth antigens within the WORMVACS2.0 project. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 27/11/20256/ Alfons Jiménez Morera is a senior technician and one of our Luminex experts 🪄 He delivered a master class on helminths 🪱 that left half of the group with their jaws on the floor because they were not aware of the devastating effects and symptoms these parasites cause. 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 27/11/20255/ If you are interested in this project, stay tuned for the upcoming paper and feel free to revisit our two previous publications on this topic: 📖 pubmed.ncbi.nlm.nih.gov/33746958/ 📖 pubmed.ncbi.nlm.nih.gov/33636218/ 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 27/11/20254/ Some of the main goals of the study are to understand: 👉 How antibodies are transferred from mothers to babies 👉 How different factors, such as maternal HIV infection, affect this transfer 👉 How humoral immunity at birth, along with these factors, shapes malaria exposure during early infancy 100
Malaria Immunology Lab at ISGlobal @malaria-immuno.bsky.social · 27/11/20253/ The iMIPPAD project focuses on the immunological analysis of serum samples collected from mothers at delivery, their cord blood and their infants. The babies are followed for up to 12 months, with several sampling visits throughout this period. 110
