Infective endocarditis due to Serratia spp. (S-IE) has historically been considered a rare entity. Typically linked to injection drug use (IDU), S-IE appears to be a growing problem as the harms of unsafe drug use proliferate. However, guidance on therapy for gram-negative IE remains limited.

Serratia spp. infective endocarditis (S-IE) is described as a rare entity associated with injection drug use (IDU). However, in a cohort of 4 US health sys

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