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Leo Pieperhoff

@lpieperhoff.bsky.social
40 followers 53 following 3 posts

PhD Candidate in multimodal MRI for preclinical Alzheimers Disease @ AmsterdamUMC

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Leo Pieperhoff @lpieperhoff.bsky.social · 11/09/2026
Interested in working on clinical, genetic and neuroimaging data in a preclinical #Alzheimers population? Check out our immensely phenotyped, openly accessible dataset! Access instructions here: amypad.eu/data/ And our recent publication describing everything MRI: doi.org/10.1038/s415...
doi.org
AMYPAD-PNHS: A Pan-European, Multi-Site & Multimodal MRI Dataset of Older Adults Without Dementia - Scientific Data
Scientific Data - AMYPAD-PNHS: A Pan-European, Multi-Site & Multimodal MRI Dataset of Older Adults Without Dementia
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Leo Pieperhoff @lpieperhoff.bsky.social · 24/06/2026
Please find our latest publication in Alzheimer's & Dementia: doi.org/10.1002/alz.... We find cortical gray-white matter tissue contrast to be a particularly early emerging MRI marker of Alzheimer's pathology, using the preclinical @imi-amypad.bsky.social Prognostic & Natural History Study!
doi.org
Cortical gray–white matter contrast alterations precede amyloid‐β positivity and macrostructural changes in older adults without dementia
INTRODUCTION Early Alzheimer's disease (AD) involves subtle cortical changes that may precede atrophy. Magnetic resonance imaging (MRI) microstructural markers may detect earlier pathology than clas...
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Reposted by Leo Pieperhoff
AMYPAD @imi-amypad.bsky.social · 15/10/2025
📢 NEW paper out in Alzheimer's & Dementia, using data from the AMYPAD Prognostic and Natural History Study! Congratulations to all authors 👏 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning
INTRODUCTION The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear. METHODS We analyzed data from 1323 individuals without a diagnosis ...
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Reposted by Leo Pieperhoff
AMYPAD @imi-amypad.bsky.social · 24/11/2025
📣New paper out on the role of cerebral amyloid-β in cortical, allocortical and subcortical atrophy in (mostly) cognitively unimpaired individuals from the AMYPAD Prognostic and Natural History Study! Congratulations to all authors👏 www.sciencedirect.com/science/arti...
sciencedirect.com
Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study
The impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer’s disease (AD), and its interaction with risk factors lik…
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Reposted by Leo Pieperhoff
katja heuer @k4tj4.bsky.social · 27/07/2025
1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
Brain Surfaces of 70 primate species
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Reposted by Leo Pieperhoff
emmacoomans.bsky.social @emmacoomans.bsky.social · 28/04/2025
So excited and honored to be invited to present the opening plenary at #AIC2025 this year in Toronto! 🧠 🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this ~5min survey: alz.surveymonkey.com/r/923BTQK
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