Reposted by Lovisa Ljungqvist BrinsonMARMO-AD @marmo-ad.bsky.social · 25/11/2024Despite rumors to the contrary, aging marmosets express both 3-Repeat and 4-Repeat isoforms of the Tau protein. This foundational result opens new avenues to understand aging, Alzheimer's disease, and neuropathology in primate models. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...alz-journals.onlinelibrary.wiley.comMarmosets as model systems for the study of Alzheimer's disease and related dementias: Substantiation of physiological tau 3R and 4R isoform expression and phosphorylationINTRODUCTION Marmosets spontaneously develop pathological hallmarks of Alzheimer's disease (AD) including amyloid beta plaques. However, tau expression in the marmoset brain has been understudied. ..... 193
