Reposted by Lindsay Hayes
Do psychiatric symptoms in epilepsy always arise from seizures? In ALDH7A1 models, seizure risk traced to the liver; mood-related behavior to astrocytes.
One gene. Two tissues. Two pathophysiologies. Neither begins in neurons.
New in Science Advances: doi.org/10.1126/scia... 1/11
doi.org
Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and maladaptive affective behaviors in epilepsy
Astrocyte antioxidant imbalance reduces neuronal activity, driving depression-like behavior in epilepsy dissociable from seizures.
