Which generation will be considered "the last to die" of age-related diseases is ultimately a question of technological development and deployment. Here's what's been done on that front in September. Interviews The Last Generation to Die: Interview With Tim Maupin: Filmmaker Tim Maupin has spent a number of years developing The Last Generation to Die,

The Biomarkers of Aging Consortium will host its fourth annual Biomarkers of Aging Conference on October 5 and 6, 2026, at the Joseph B. Martin Conference Center at Harvard Medical School. The meeting brings together academic, clinical, industry, regulatory, and philanthropic leaders working to develop, validate, and apply biomarkers of aging. Therapies that target aging

At a panel in Boston, senior officials announced plans to include aging in the agency’s regulatory science agenda and discussed how therapies could move toward approval. Longevity has a partner The 2026 edition of the Aging Research and Drug Discovery Meeting (ARDD) kicked off yesterday. This is one of the biggest and longest-running longevity conferences,

A new preprint study suggests that transplanted hearts’ epigenetic age and possibly function are influenced by their recipients’ age.

Researchers have created a deep learning-based biomarker, SASP Score, that evaluates the combined effects of the senescence-associated secretory phenotype (SASP) circulating in the bloodstream. Measuring an overall burden Gathering the data needed to evaluate a person's circulating SASP is as simple as taking a blood draw. However, as bloodstream SASP is a combination of many

According to a new study, creatine supplementation might help maintain and increase lean mass even without diet or exercise. It also enhanced the effects of a combined diet and exercise intervention [1]. How to lose weight but not muscle As people age, they often accumulate fat while losing muscle. When these changes occur together, in

Researchers have discovered that BNIP3, which regulates mitochondrial maintenance, is increased with aging, harming the heart's ability to process energy. Mitochondrial transplantation was found to be effective against this increase in a mouse model. The heart needs energy Mitophagy, the process of eliminating damaged mitochondria, is necessary for the proper function of organs and staving

Results from a recent study suggest a delay in ovarian aging in mice following treadmill training; this effect was mediated by adiponectin. Pharmacologically activating adiponectin receptors extended reproductive span in mice. [1] Beyond reproduction The female reproductive system strongly influences the female aging trajectory, and its impact goes well beyond the cessation of reproduction. While

According to a new study using a mouse model of a rare disease, transplanted immune cells donate their mitochondria to neighboring donor cells, improving energy production and rescuing function [1]. Here, have some mitochondria Friedreich’s ataxia is a rare genetic disease in which deficiency in the protein frataxin impairs mitochondrial energy production, especially in energy-hungry

In a pilot study, patients engaging in intermittent fasting demonstrated improvements in Huntington's disease, a neurodegenerative condition currently considered untreatable. However, the study’s size and limitations call for more research [1]. Fast to survive Huntington’s disease is an inherited, progressive neurodegenerative disorder caused by an expansion of a repeated DNA sequence in the HTT gene,

In a new study, thymic tissue implanted in the spleen improved immune responses against viruses and tumors and reversed age-related thymic involution in mice [1]. Growing one organ inside another The thymus is a small but crucial organ, where T cells mature to become the backbone of our adaptive immune system. There, they acquire their

Researchers publishing in Aging Cell have found that a cocktail of molecules released by human umbilical cord mesenchymal stem cells (hUC-MSCs) can mitigate sun-induced skin aging (photoaging) in mice by restoring their cells' ability to get rid of their own damaged mitochondria (mitophagy). Wrinkles are only a small part of the problem Chronic exposure to

Researchers have established how a protein that is nearly absent in the literature, PTCHD4, is linked to cellular senescence. Very little previous work In most papers, after a customary discussion of the mechanics of cellular senescence and current methods of handling it and its repercussions, the researchers go on to discuss previous work relating to

A team of researchers has discovered that mitochondrial health and location may be critical to why cognitive plasticity decreases with age. Old mammals and new tricks The adage 'you can't teach an old dog new tricks' is true across a wide variety of organisms; neural plasticity decreases with age in rodents, non-human primates, and people

Six different aging clocks detected younger blood protein profiles in patients taking the experimental lung-fibrosis drug rentosertib.

With Grok Bot, SpaceXAi has created something really special and helpful. And the Evipedia Grok Bot turns this gem into something even more precious. A specialized AI assistant offering an evidence-based 2nd opinion on health and longevity interventions. It integrates Grok, the AI4L persona, the Evipedia MCP server, and Evipedia-hosted search into one super-useful companion. What Evipedia Grok Bot will do for

Fresh from Spain’s spectacular victory in the 2026 FIFA World Cup, Madrid is preparing for another kind of world-class gathering: one focused not on winning more years of sporting glory, but on winning more healthy years of life. On September 30 and October 1, 2026, the International Longevity Summit Madrid 2026 will bring together leading

Researchers have discovered and explained how calcium mishandling in muscle cells leads to long-term muscle weakness in older people. Calcium is not just for bones Skeletal muscle cells use calcium ions to control how and when they contract. This activity is modulated by CaMKII, a protein kinase that also regulates muscle adaptations in response to

In a recent study, researchers have evaluated how responsive several DNA methylation (DNAm) biomarkers are to a range of longevity interventions [1]. Waiting too long Testing lifespan-extending interventions in humans has a major problem: it can take many years, or even decades, to see results. Nobody wants to wait that long. Therefore, it is essential

In a new study, semaglutide given late in life increased median lifespan in female mice by more than 12% and improved various health markers. Semaglutide’s effect possibly went beyond caloric restriction [1]. Old mice, new drugs GLP-1 receptor agonists, which act on a hormone that regulates insulin secretion and appetite, have revolutionized obesity treatment, showing

Researchers publishing in Aging Cell have described how stopping growth hormone receptor production in midlife significantly lengthens the lives of mice.

Tim Maupin has spent years developing The Last Generation to Die, a near-future film about what happens when the first true rejuvenation technologies arrive.

Driven by ongoing support from their community, The Longevity Science Foundation is extending the deadline for the Invested in Her campaign to October 1, 2026.

Properly untangling aging means untangling its various counterbalances, sometimes on the individual level. Here's what's been investigated this month. Interviews Wei-Wu He: People Should Become the CEOs of Their Own Health: Wei-Wu He is an unusual combination of scientist and businessman, and his current company focuses on using precision medicine to lengthen people's lives. Michael

Researchers have found that the sirtuin SIRT1 stabilizes the human genome by suppressing retrotransposition, which occurs when parts of the genome transcribe themselves onto other parts. When DNA modifies itself Long interspersed elements-1 (LINE-1) have existed in organisms' genomes, including our own, for well over a billion years [1]. They are the only autonomous elements

Michael Snyder, Director of the Center for Genomics and Personalized Medicine at Stanford University, is obsessed with health-tracking wearables. During our interview, he wore four wrist-worn devices – watches and bands – and two rings. He is convinced that these small but powerful gadgets will help drive the transition from today’s “sickcare” to true healthcare,

A recent study has examined whether senescence might allow cancer cells to survive oncogene withdrawal and become even more dangerous [1]. Some blocking techniques are temporary Many cancers depend heavily on a particular oncogenic signal to maintain their growth. Drugs that block these drivers can, therefore, produce dramatic tumor shrinkage. A major clinical problem, however,

A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs. long and moderate Exercise is a well-known lifestyle factor that can positively impact health. Exercise benefits multiple cells,

Researchers have found that an upstream promoter of two extracellular matrix proteins increases healing and strength capabilities in the tendons of rats. Tendon injuries in older people Previous research has found that, like with many other injuries, tendon injuries have an age-related component. The tendons of the biceps and rotator cuffs are more commonly injured

A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling [1]. The living dead Amyotrophic lateral sclerosis (ALS), an age-related neurodegenerative disease, is characterized by the progressive loss of motor neurons. Historically, much of ALS

Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. Too much of a regulator leads to dysregulation This paper introduces itself with a standard explanation of the relationship between senescence and

This AI startup, which lists Nobel laureate David Baker among its co-founders, has announced a “world model” of a cell that can simulate both its natural state and responses to successive perturbations, potentially transforming biological research. Living in a simulation Simulating a living organism on a computer (in silico) has been a dream of both

Researchers have gone into deep detail regarding how each of five senescent brain cell types expresses and receives factors that encourage other cells to become senescent. The contagion of age This paper revolves around paracrine senescence: SASP factors being emitted by primary senescent cells to drive secondary senescence in other cells [1]. Senescent cells differ

A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest a therapeutic route [1]. Longevity hidden in the genome For decades, aging researchers have hoped that human genetics might reveal genuine “longevity genes” whose altered

In Aging, the Conboys and their team have described how a combination treatment kills both senescent and cancer cells and lengthens the lives of old mice. Of senescence and cancer Just as it does in mice, the incidence of cancer rises with age in people [1]. Among other things, senescence is an evolved defense against

Staying informed about health and longevity interventions can be tedious and time-consuming. Often it involves manually decoding a supplement label with numerous compounds, reading a blog post about some therapy, or an X-post that name- drops a peptide — and having to look up every item manually. The Evipedia browser extension takes this challenge head-on.

A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner.

A new study proposes a theoretical framework that explains why the more complex an animal is, the harder it is to move the needle on its rate of aging.

Researchers have discovered why the protein AGGF1 has significant effects on blood pressure and published their findings in Aging Cell. Blood pressure is a condition of its own The authors begin their paper by discussing high blood pressure (hypertension), one of the most commonly known medical issues and a significant contributor to both disability and

Wei-Wu He is an unusual combination of scientist and businessman, with a record of founding and leading several successful companies.

A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. Epigenetics versus transcriptomics The authors begin by discussing the strengths and limitations of conventional methylation-based epigenetic clocks. They note that while such clocks have good prediction abilities as a whole, they are technically

There is a clear economic necessity: transitioning our medical framework from reactive maintenance to preventative biomedical repair.

A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased liver mitochondrial activity emerged as a leading clue. Protein composition matters The debates around how much protein people should consume to maximize their healthspan and

The fight for longevity treatments that measurably improve and lengthen quality of life is ongoing in research, treatment, and policy, with promising successes and a horrifying failure. Here's what's happened in July. Interviews Gabriel Cian on Building the 2060 Longevity Ecosystem: In this follow-up interview, we speak with Gabriel Cian about how the 2060 ecosystem

For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in Health at the University of Porto, has been studying inflammation and its crucial role in aging and disease. Earlier this month, he received the Rising

A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and biological reliability The authors make a clear distinction between technical and biological reliability. A technically reliable clock is one that consistently gives the same outputs

Montana’s first experimental treatment review board has brought three longevity heavyweights into the state’s effort to expand access to experimental therapies. How much regulation is too much? Many people in the longevity field will tell you that regulation is holding it back. Sensible oversight of novel therapies is essential, but an overly cautious interpretation of

Researchers have published an explanation of how neutrophil extracellular traps worsen UVB damage and how an inhibitor alleviated this damage in a mouse model.

According to the experts that we spoke to, the death underscores the risks of unproven treatments and the need for rigorous longevity medicine.