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Le Wang

@lewang1.bsky.social

29 followers 78 following 0 posts

Neuroscience, genetics. opinion my own.

Posts Replies Media

Reposted by Le Wang

The Science of Parkinson's @scienceofpd.bsky.social · 05/03/2026

Single-nucleus multiomic profiling of aging mouse substantia nigra reveals conserved gene alterations linked to #Parkinsons; Hsp90aa1 & Hsp90ab1⬆️in oligodendrocytes & microglia, Apoe⬆️in microglia, & protein folding genes⬆️in oligo.s at late aging stages genome.cshlp.org/content/earl...

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Reposted by Le Wang

Mark Rossi @markrossi.bsky.social · 17/11/2025

The final version of this paper is now online at iScience www.cell.com/iscience/ful...

cell.com

Individual paraventricular hypothalamic GLP-1R neurons track ingestion across energy states

Energy homeostasis is tightly regulated to ensure metabolic health in uncertain environments. Neurons expressing the glucagon-like peptide-1 receptor (GLP-1R) contribute to maintaining body weight, bu...

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Reposted by Le Wang

Mark Rossi @markrossi.bsky.social · 15/09/2025

🚨 New preprint from an ongoing collaboration with the Pang lab. Project led by rising stars @rohansavani.bsky.social and @lewang1.bsky.social showing how individual GLP-1R neurons in the paraventricular hypothalamus track ingestion across energy states. Preprint: papers.ssrn.com/sol3/papers....

papers.ssrn.com

Individual Paraventricular Hypothalamic GLP-1R Neurons Track Ingestion Across Energy States

Energy homeostasis is tightly regulated to ensure metabolic health in the face of uncertain environments. Changes in energy states or circulating hormonal signa

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