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lenawirth.bsky.social @lenawirth.bsky.social · 25/02/2025

1/Excited to share our latest work in Cancer Discovery @theaacr.bsky.social. Led with #MiyaHugaboom and @kstreet.bsky.social, we show that the presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical responses to PD-1 blockade in #RCC: brnw.ch/21wQUU4

brnw.ch

Presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma

Abstract. Immune checkpoint inhibitors (ICI) targeting the PD-1 pathway have transformed treatment of advanced renal cell carcinoma (RCC), but mechanisms underlying therapeutic response remain largely...

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