This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

This study identifies a specific role for ceramide synthase 4 (CerS4) in cell fate regulation. Epidermis-specific deletion of CerS4 prevents development of

Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...