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laurelrobbins.bsky.social

@laurelrobbins.bsky.social

PhD Candidate at CU Boulder in Aaron Whiteley's Lab she/her

laurelrobbins.bsky.social @laurelrobbins.bsky.social · 05/05/2026

We found that bNACHT11 re-localizes following activation and initiates plasmolysis, a process where the inner membrane collapses due to outward osmotic flux of water.

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laurelrobbins.bsky.social @laurelrobbins.bsky.social · 05/05/2026

β-augmentation describes when a β-strand from one protein forms an anti-parallel β-sheet with a β-strand from another protein. β-augmentation was found at the interface of bNACHT11 and each of the other phage protein activators.

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laurelrobbins.bsky.social @laurelrobbins.bsky.social · 05/05/2026

We wanted to better understand how bNACHT11 accomplishes this sensing feat. In collaboration with the Corbett Lab at UCSD, @amardeeep.bsky.social determined a cryoEM structure of bNACHT11 activated by the phage protein T2 gp57.

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