A mathematical breakthrough depended on AI—but also on a creative human insight

At the Human Proteome Organization World Congress, researchers turn from building tools to finding out what they can do

An exploration of the nomination data behind the Nobel Prize in Chemistry

Test yourself on your science Nobel knowledge. Plus, how butterfly markings mislead the eye and how to respond to hate speech without fuelling it further.

The allotrope cyclo-octasulfur may help buffer lipid oxidation

Today we announced the Claude-led discovery of a molecular machine that we suspect could represent a new gene editing mechanism. Its precise function, biotechnological utility (if any), or level of significance is not yet clear, but at minimum it is work I would have been proud to do as a PhD stude…

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Drug development requires evidence integration across biological scales and modalities, but relevant tools are fragmented. We introduce the Virtual Biotech, an organization of artificial intelligence ...

With new datasets, community seeks ‘AlphaFold moment’ for small molecules

Primer, heat, and water could all help explain the failures in the pool’s new polymer lining

In July, the prediction market platform Kalshi and data company AppliedXL began a pilot market listing binary, yes-or-no contracts on whether named late-stage clinical trials meet their preregistered ...

As artificial intelligence drives breakthroughs in chemistry, the intellectual property community is struggling to keep pace

Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudi...

Lab animals on the drug live longer, mimicking well-known effects of caloric restriction

Sheo Pharmaceuticals scientists queried AI tools about failed renin inhibitors and then built their own

C&EN explores which cities have the ingredients for chemical innovation

First-time disclosures session at ACS Fall 2026 debuted compounds designed to treat cancer, acne, urinary tract infections, and more

Can a drug company own every monoclonal antibody in a class — even the ones they don’t know about?