Evading lysosomal degradation is of critical importance to successful intracellular pathogens. The lysosome, classically considered the waste disposal and recycling center of the cell, is a hostile en...

Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

While the cysteine proteases legumain and cathepsins have traditionally been known as “lysosomal” proteases, there is increasing evidence to suggest that they also contribute to a wide range of ext...

Families can wait years for a diagnosis of a rare genetic disorder, but a new test can provide answers in days for a better understanding of the condition and potentially earlier treatment, finds new...

The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...

The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...

I'm excited to share the next issue of QuickCuts reporting news from the International Proteolysis Society. Registration for the next general meeting in Brazil is now open, so don't miss out! ...