Steve Pressé @labpresse.bsky.social · 21/07/2026The new 50% US tariffs imposed by the Trump administration affect ~ $20B imported from 🇨🇦, which translates to ~ 5.2% of U.S. goods imported from 🇨🇦 Straight out the academic handbook: not picking one’s battles and ruining one’s reputation over a 2.6% net change. 000
Steve Pressé @labpresse.bsky.social · 14/07/2026Our recent PNAS and Nature Communications papers were recently featured in ASU News. Check it out!! news.asu.edu/20260701-sci... A testament to our great team. #ASU #PNAS #NatureCommunications #Biophysics #Bayesiannews.asu.eduASU scientists unveil new methods to extract reliable truth from imperfect data | ASU NewsScientists at Arizona State University are advancing how they interpret complex, imperfect data — challenging long-standing assumptions in fields ranging from imaging to cellular biology. In two paper... 010
Steve Pressé @labpresse.bsky.social · 07/06/2026Today, we are expanding that foundation by combining quantitative science and AI to address some of the most important challenges in human health. I am excited to work with colleagues across ASU and our clinical partners to build this next chapter of interdisciplinary biomedical research. 100
Steve Pressé @labpresse.bsky.social · 07/06/2026integrative models of health and disease across multiple biological scales. Our roots are in Single Molecule Biophysics, a field that has transformed our understanding of biological systems through molecular-level precision. 100
Steve Pressé @labpresse.bsky.social · 07/06/2026data-driven approaches that support earlier diagnosis, more precise therapies, and better patient outcomes. To achieve this, we are bringing together faculty from medicine, biology, chemistry, physics, statistics, computer science, and engineering to build 110
Steve Pressé @labpresse.bsky.social · 07/06/2026Our Center will work closely with the ASU John Shufeldt School of Medicine and Medical Engineering to accelerate translational research and bridge fundamental discovery with clinical application. Our goal is to develop physics-inspired, 100
Steve Pressé @labpresse.bsky.social · 07/06/2026improving the interpretation of retinal and tomographic imaging, or modeling how proteins dynamically change shape and respond to therapies, the future of medicine will depend on the convergence of data, physics, biology, and computation. 100
Steve Pressé @labpresse.bsky.social · 07/06/2026from single molecules to cells, tissues, and disease. We believe that AI achieves its greatest clinical impact when combined with rigorous scientific understanding. Whether detecting early hallmarks of neurodegenerative disease from subtle patterns in microscopy data, 100
Steve Pressé @labpresse.bsky.social · 07/06/2026#SingleMoleculeBiophysics #ComputationalBiology #BayesianInference #ArizonaStateUniversity #BiodesignInstitute Our vision is to advance personalized medicine by integrating artificial intelligence, quantitative modeling, and biomedical expertise across scales— 101
Steve Pressé @labpresse.bsky.social · 07/06/2026🚀 Major Announcement I am honored to announce my new role as Director of the Center for Single Molecule Biophysics in ASU Biodesign Institute. biodesign.asu.edu/single-molec... #ArtificialIntelligence #BiomedicalResearch #Biophysics #PrecisionMedicinebiodesign.asu.eduCenter for Single Molecule Biophysics | ASU Biodesign InstituteThe Biodesign Center for Single Molecule Biophysics allows researchers to study the physical processes on which life is based using cells and tissue. 171
Steve Pressé @labpresse.bsky.social · 20/05/2026 (E. Coli) bacteria in the environment rather than acting within the host! 000
Steve Pressé @labpresse.bsky.social · 20/05/2026New preprint “𝗦𝘁𝗼𝗰𝗵𝗮𝘀𝘁𝗶𝗰 𝗰𝗼𝗹𝗼𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗵𝗼𝘀𝘁-𝘁𝗼-𝗵𝗼𝘀𝘁 𝘁𝗿𝗮𝗻𝘀𝗺𝗶𝘀𝘀𝗶𝗼𝗻 𝘀𝗵𝗮𝗽𝗲 𝗴𝘂𝘁 𝗯𝗮𝗰𝘁𝗲𝗿𝗶𝗮𝗹 𝘃𝗮𝗿𝗶𝗮𝗯𝗶𝗹𝗶𝘁𝘆.” www.biorxiv.org/content/10.6... Using C. elegans as host, we find that bacterial predators (bdellovibrio) act through suppression of host to host transmission of gut-expelled preybiorxiv.org 131
Reposted by Steve PresséAIP Publishing @aip-publishing.bsky.social · 28/01/2026From widefield to confocal tracking and from single-spot to photon-array detectors, we chart the move beyond localization–linking toward integrative methods for crowded, superresolved tracking. @labpresse.bsky.social Learn more 👇 aippub.org/4qmTTFS 001
Steve Pressé @labpresse.bsky.social · 03/02/2026Specifically, MERFISH data where raw (or minimally processed / registered) images are available across rounds/bits, and where z-planes are sampled densely enough to justify explicit 3D modeling (ideally dz ≤ 0.5 µm; even ~0.75 µm would be workable depending on optics). 000
Steve Pressé @labpresse.bsky.social · 03/02/2026Help!!! We're working on a Bayesian approach for decoding MERFISH images in 3D, and we’re trying to identify an accessible MERFISH dataset that’s “truly volumetric” in the imaging sense. Even a pointer to the right paper, repository, or person to ask would be helpful. Thanks so much! 100
Steve Pressé @labpresse.bsky.social · 12/01/2026When is it ok to invoke a small Reynolds number approximation in finite temperature fluids? For spatially correlated fluids, curiously the answer is…never? 🧐 arxiv.org/html/2601.05... #fluids #fluidphysicsarxiv.orgRevisiting the scale dependence of the Reynolds number in correlated fluctuating fluids 041
Steve Pressé @labpresse.bsky.social · 21/12/2025It’s been 30 yrs since Zwanzig’s “non-eq stat mech” As written, it has solidified the notion that theory develops models, and MD (perhaps) should be left to parametrize. Maybe it’s time to re-pitch the work using functional integrals & tie this formulation to likelihoods :) 010
Reposted by Steve PresséAlessandro Rigolon @alerigolon.bsky.social · 20/12/2025Really interesting research showing that while ultra-specialization in a single discipline might lead to better results early in one’s career, multi-discipline training and practice pays off big time in the long run. This applies to a range of professions from scientists to athletes and morescience.orgRecent discoveries on the acquisition of the highest levels of human performanceScientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re... 1002048444
Steve Pressé @labpresse.bsky.social · 20/12/2025A bit of an emotional pic. A Silbey lab reunion of sorts in Honolulu. L2R: @LabPresse, Jaeyoung Sung, Yuen-Chung Cheng, YoonJoon Jung, Alex Tkachenko. Haven’t seen some people in ~20 yrs 😢 010
Steve Pressé @labpresse.bsky.social · 16/12/2025Happy to be @acs.org #pacifichem with L2R Banu Ozkan, Jaeyoung Sung, Matthias Heyden, and @labpresse.bsky.social for our joint @arizonastateuni.bsky.social Center for Biological Physics - Chung Ang GCSC symposium. Especially happy about Mai Tai’s 🍹 010
Steve Pressé @labpresse.bsky.social · 02/12/2025Our latest JChemPhys selected as highlight. Our title communicates it all :) “A cautious user’s guide in applying HMMs to physical systems” pubs.aip.org/aip/jcp/arti...pubs.aip.orgA cautious user’s guide in applying HMMs to physical systemsNature, as far as we know, evolves continuously through space and time. Yet, the ubiquitous hidden Markov model (HMM)—originally developed for discrete time and 000
Steve Pressé @labpresse.bsky.social · 05/11/2025ASU Physics is searching for a new Chair. If interested, please apply. Feel free to contact me with any questions. We are seeking, first and foremost, a leader & world-class scientist with a strong research record apply.interfolio.com/176489 #asu #ASUResearchapply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 020
Steve Pressé @labpresse.bsky.social · 03/11/2025Lab Halloween fun before lab reception for Weiqing Xu’s departure to the lab of @jonasries.bsky.social We will miss you Weiqing! 040
Steve Pressé @labpresse.bsky.social · 31/10/2025Here is the original: pubs.aip.org/aip/jcp/arti...pubs.aip.orgPerspective: An outlook on fluorescence trackingTracking single fluorescent molecules has provided new insights into dynamic molecular processes at the single-molecule level. This Perspective traces the evolu 010
Steve Pressé @labpresse.bsky.social · 30/10/2025Tracking has always been at the ❤️ of the scientific method, from planetary motion to single particles. Weiqing’s thesis intro on tracking was so beautiful we turned it into a perspective in JCP who then selected it as a #Scilight. Take a look! 😊 www.aip.org/scilights/tr...aip.orgTracing fluorescence tracking’s past, present, and futureArtificial intelligence and parallel computing could refine studies of the movement of single molecules inside cells. 1286
Steve Pressé @labpresse.bsky.social · 23/10/2025News story our APS fellowship. A testament to the great people we work with (and the unwavering rigor of Bayesian approaches, impervious to hype) 😊 🙏 news.asu.edu/b/20251021-a...news.asu.eduASU chemistry and physics professor elected to prestigious fellowship | ASU NewsSteve Pressé, professor in Arizona State University’s School of Molecular Sciences and Department of Physics, has been elected as a 2025 American Physical Society Fellow for his leadership and excepti... 051
Steve Pressé @labpresse.bsky.social · 12/10/2025It’s an Honor to be named 2025 @apsphysics.bsky.social Fellow. 🙏 our lab members and collaborators. Citation: “For pioneering contributions to Bayesian method development in biological physics, particularly […] to imaging and single-molecule experiments. #APSFellow 170
Steve Pressé @labpresse.bsky.social · 11/09/2025The journey continues. UT Austin and Oden tomorrow and Friday. Here with Dima Makarov :) (Discussing Bach, Richter, Gould, Yuja Wang, and maybe some single molecule 😊) 140
Steve Pressé @labpresse.bsky.social · 10/09/2025One of my favorites by Voltaire in describing Canada “quelques arpents de neige, habités par des barbares, des ours et des castors” 🙃 110
Steve Pressé @labpresse.bsky.social · 10/09/2025Thanks to the CTBP for the wonderful invitation for a seminar at Rice! 🙏 Joining me are Tolya Kolomeisky and Oleg Igoshin. 050
Reposted by Steve PresséPedro Pessoa, PhD @pedropessoaphd.bsky.social · 08/09/2025Hello everyone, Tomorrow I’ll be giving a chalk talk on our new eLife: “REPOP: bacterial population quantification from plate counts” elifesciences.org/reviewed-pre... Looking forward to seeing you!! #eLife #datascience #biophysics #bioinformatics #Bayesian #REPOP 252
Steve Pressé @labpresse.bsky.social · 12/08/2025Can we learn motion models from post-processed tracks? 🧐 Not really 😢 Emission noise accounts for ~99% of the likelihood. TLDR: What you think is anomalous diffusion… might just be noise. 🤷♂️🤷♂️🤷♂️🤷♂️ 🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599 #Biophysicsarxiv.orgHow Easy Is It to Learn Motion Models from Widefield Fluorescence Single Particle Tracks?Motion models (i.e., transition probability densities) are often deduced from fluorescence widefield tracking experiments by analyzing single-particle trajectories post-processed from data. This analy... 153
Steve Pressé @labpresse.bsky.social · 06/08/20256/6 If you plate, you need REPOP. Software -- github.com/PessoaP/REPOP Preprint -- elifesciences.org/reviewed-pre... Special thanks to the Lab Members @pedropessoaphd.bsky.social, Carol Lu and Stanimir Tashev As well as Rory Kruithoff and @dpshepherd.bsky.social #Biophysics #QuantitativeBiologygithub.comGitHub - PessoaP/REPOPContribute to PessoaP/REPOP development by creating an account on GitHub. 000
Steve Pressé @labpresse.bsky.social · 06/08/20255/6 This is why we built REPOP, an #opensource tool to REconstruct POpulations from Plates. Straightforward to use and with tutorials available on #GitHub github.com/PessoaP/REPOP With all the #Bayesian rigor and #PyTorch speedgithub.comGitHub - PessoaP/REPOPContribute to PessoaP/REPOP development by creating an account on GitHub. 121
Steve Pressé @labpresse.bsky.social · 06/08/20254/6 As we show in the paper, this - Overestimatese variability - Can miss real structure in your population: Subpopulations and/or multimodality as biological differences across samples, 100
Steve Pressé @labpresse.bsky.social · 06/08/20253/6 This assumes: – No randomness in how many bacteria end up on the plate – No randomness in the original swab In reality, every step is noisy. 100
Steve Pressé @labpresse.bsky.social · 06/08/20252/6 Plate counting is a simple: You dilute a sample, plate a small volume, and count colonies. Say you dilute by 200×, and count 50 colonies. Easy just multiply 50 × 200 = 10k bacteria, right? NOT QUITE... 100
Steve Pressé @labpresse.bsky.social · 06/08/2025Hello all, If you do #PlateCounting, you may want to take a look at our new eLife @elife.bsky.social If you don't, I still encourage you to join for an interesting discussion. Follow the thread 🧵 elifesciences.org/reviewed-pre... #Microbiology #DataScience #PyTorch #QuantitativeBiology #REPOPelifesciences.orgREPOP: bacterial population quantification from plate counts 132
Steve Pressé @labpresse.bsky.social · 05/08/20253/3 In it, we simulate some general physical systems that violate the HMM's assumptions and demonstrate contradictory results that can arise. Surprisingly, the problems with HMM analysis only grow with better data acquisition (higher data acquisition rate and/or reduced noise). 000
Steve Pressé @labpresse.bsky.social · 05/08/20252/3 HMM are classic in time series analysis, but they can yield confusing, seemingly contradictory results. In particular, when applying HMMs to physical systems where two key HMM assumptions, that state spaces are discrete, and that transitions are instantaneous, don't apply. 100
Steve Pressé @labpresse.bsky.social · 05/08/2025Have you ever applied a Hidden Markov Model (HMM)? Does the results seems contradictory? If so, you are going to love our new preprint: arxiv.org/abs/2506.05707arxiv.orgA cautious user's guide in applying HMMs to physical systemsNature, as far as we know, evolves continuously through space and time. Yet the ubiquitous hidden Markov model (HMM)--originally developed for discrete time and space analysis in natural language proc... 120
Reposted by Steve PresséPedro Pessoa, PhD @pedropessoaphd.bsky.social · 05/08/2025So… I was googling myself and made quite a discovery 🎧 There's an AI-generated podcast of my #TimeSeriesForecasting paper 🤔🤔 www.youtube.com/watch?v=3BNz... Not sure whether to feel flattered, creeped out, or alarmed. That is the future I guess 🤷♂️🤷♂️ To read the full paper: doi.org/10.1088/2632...youtube.comMamba time series forecasting with uncertainty quantificationYouTube video by Xiaol.x 011
Steve Pressé @labpresse.bsky.social · 04/08/2025The Pressé Lab is happy to join the #biophysics #imaging & #singlemolecule scientific communities here. Hopefully high SNR messaging from this account about low SNR data :) #science #machinelearning #datamodeling 0165