Laboratory Investigation @labinvest.bsky.social · 24/09/2026New from Laboratory Investigation 🔬 | Integrating molecular, histopathologic, and spatial transcriptomic profiling reveals shared pathogenic features of lymphatic malformations and highlights NFATC1 activation in lymphatic endothelial cells. 🔗 Hirose et al. Read the article buff.ly/NgRf8ra 000
Laboratory Investigation @labinvest.bsky.social · 22/09/2026New from Laboratory Investigation 🔬 | Optimizing DNA extraction from archival prostate biopsies to maximize DNA yield from limited tumor samples for molecular testing. 🔗 Amaral et al. Read the article: www.laboratoryinvestigation.org/article/S002...laboratoryinvestigation.orgOptimizing DNA Extraction from Archival Prostate Biopsy SamplesIn this paper, we compare the performance of three distinct nucleic acid extraction protocols in a large population-based prostate cancer cohort, aiming to optimize DNA yield from limited tumor… 000
Laboratory Investigation @labinvest.bsky.social · 18/09/2026New from Laboratory Investigation 🔬 | Identifying two novel compound heterozygous ADAMTS17 variants associated with Weill–Marchesani syndrome 4, including a deep intronic variant shown to disrupt normal splicing. 🔗 Ku et al. Read the article: www.laboratoryinvestigation.org/article/S002... 010
Laboratory Investigation @labinvest.bsky.social · 26/08/2026New from Laboratory Investigation 🔬 | Renal Pathology Society Survey of Global Renal Pathology Practice Variation in Pre-analytic and Analytic Phases @Renalpathsoc 🔗 Gaut et al. Read the article: www.laboratoryinvestigation.org/article/S002...laboratoryinvestigation.orgRenal Pathology Society Survey of Global Renal Pathology Practice Variation in Pre-analytic and Analytic PhasesThis study aims to examine current global renal biopsy pre-analytic and analytic variability according to country income status. Technology access, pathologist workforce, and case volume variations… 000
Laboratory Investigation @labinvest.bsky.social · 26/08/2026New from Laboratory Investigation 🔬 | Spatial Transcriptomics of Micropapillary, Plasmacytoid, and Sarcomatoid Urothelial Carcinoma Reveals Distinct Molecular Landscapes @TingZhaoPathdoc 🔗 Zhao et al. Read the article: www.laboratoryinvestigation.org/article/S002...laboratoryinvestigation.orgSpatial Transcriptomics of Micropapillary, Plasmacytoid, and Sarcomatoid Urothelial Carcinoma Reveals Distinct Molecular LandscapesConsensus molecular classes of urothelial carcinoma (UC) include basal/squamous (Ba/Sq), luminal papillary (LumP), luminal nonspecified (LumNS), luminal unstable (LumU), stroma-rich, and… 000
Laboratory Investigation @labinvest.bsky.social · 26/08/2026New from Laboratory Investigation 🔬 | Prediction of Lymph Node Metastasis in Early Gastric Cancer Using Foundation Model Ensembles and Patch-Based Histopathological Interpretation 🔗 Chung et al. Read the article: www.laboratoryinvestigation.org/article/S002...laboratoryinvestigation.orgPrediction of Lymph Node Metastasis in Early Gastric Cancer Using Foundation Model Ensembles and Patch-Based Histopathological InterpretationAccurate prediction of lymph node metastasis (LNM) remains challenging in early gastric cancer (EGC), particularly when determining the need for additional surgery after endoscopic resection. We… 000
Laboratory Investigation @labinvest.bsky.social · 26/08/2026New from Laboratory Investigation 🔬 | Renal Pathology Society Survey of Global Renal Pathology Practice Variation in Pre-analytic and Analytic Phases @Renalpathsoc 🔗 Gaut et al. Read the article: www.sciencedirect.com/science/arti...sciencedirect.comhttps://www.sciencedirect.com/science/article/pii/S0023683726000899 000
Laboratory Investigation @labinvest.bsky.social · 26/08/2026New from Laboratory Investigation 🔬 | Spatial Transcriptomics of Micropapillary, Plasmacytoid, and Sarcomatoid Urothelial Carcinoma Reveals Distinct Molecular Landscapes @TingZhaoPathdoc 🔗 Zhao et al. Read the article: www.sciencedirect.com/science/arti...sciencedirect.comhttps://www.sciencedirect.com/science/article/pii/S0023683726000905 000
Laboratory Investigation @labinvest.bsky.social · 26/08/2026New from Laboratory Investigation 🔬 | Prediction of Lymph Node Metastasis in Early Gastric Cancer Using Foundation Model Ensembles and Patch-Based Histopathological Interpretation 🔗 Chung et al. Read the article: www.sciencedirect.com/science/arti... 000
Laboratory Investigation @labinvest.bsky.social · 13/08/2026New from Laboratory Investigation 🔬 | Intratumoral macrophage subsets and CD8 are associated with favorable outcomes during PD-1–based immunotherapy #openaccess 🔗 Ohkuma et al. Read the article: www.laboratoryinvestigation.org/article/S002...laboratoryinvestigation.orgAssociation of Intratumoral Macrophage Subsets with Treatment Outcomes in Patients with Stage IV Solid TumorsTo assess whether pretreatment intratumoral macrophage-associated and T-cell marker-positive areas are associated with treatment outcomes in patients with stage IV solid tumors receiving programmed… 000
Laboratory Investigation @labinvest.bsky.social · 24/03/2025THE #USCAP2025 EXHIBIT HALL IS OPEN! Make sure to stop by the USCAP booth in the center of the Exhibit Hall to say hi to your FAVORITE #ModernPathology and #LaboratoryInvestigation JOURNAL MANAGERS! #Pathology 010
Laboratory Investigation @labinvest.bsky.social · 23/03/2025Laboratory Investigation is an international journal owned by the United States and Canadian Academy of #Pathology. Laboratory Investigation offers prompt publication of high-quality original research that advances the understanding and classification of #humandisease. WE ARE AT #USCAP2025! 010