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Karim Labib @labiblab.bsky.social · 03/02/2025

Here's out latest manuscript, showing how the replisome is marked for destruction during mitosis, to trigger the processing of sites of incomplete DNA replication. www.biorxiv.org/content/10.1...

biorxiv.org

TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Polε

Mammalian cells frequently enter mitosis before DNA replication has finished, necessitating the rapid processing of replication forks to facilitate chromosome segregation. The TRAIP ubiquitin ligase i...

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