I am so excited to share our new preprint!
www.biorxiv.org/cgi/content/...
This work uncovers a key molecular mechanism that control synapse-specific exposure of the canonical “eat-me” signal phosphatidylserine!
biorxiv.org
Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling
Neuronal synapses are eliminated during brain development and disease through pruning by glial cells. Individual synapses are marked for engulfment by 'eat-me' signals, which include externalized phos...