Haue, Holm et al. use unsupervised clustering to subgroup a large set of ischemic heart disease patients from their pre-existing diseases, covering the entire multimorbidity spectrum. They identify subgroups that have different risk profiles and are characterized by different patterns when looking at patient blood tests and genetic profiles.

Hear the biggest stories from the world of science | 21 May 2025

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

A genome-wide association study meta-analysis combined with multiomics data of osteoarthritis identifies 700 effector genes as well as biological processes with a convergent involvement of multiple effector genes; 10% of these genes express the target of approved drugs.