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Karin Prummel

@kprummel.bsky.social
167 followers 233 following 21 posts

SNSF and EMBO Postdoctoral fellow at EMBL | PhD in Dev Bio from University of Zurich | Utrecht University alumni | climbing | cycling | piano

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Karin Prummel @kprummel.bsky.social · 19/11/2025
🎯 Inflammation and niche remodelling are hallmarks in both CHIP to MDS, underscoring the role of the microenvironment in early myeloid disease. Targeting this stromal-immune remodelling could open new interception strategies.
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Karin Prummel @kprummel.bsky.social · 19/11/2025
In co-culture experiments 🧫, we showed that healthy & CHIP HSPCs engaged with stromal cells to receive support 🩸🫂(e.g., CXCL12), but MDS HSPCs failed to do so. MDS blasts (!) even triggered an inflammatory program in stromal cells.
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Karin Prummel @kprummel.bsky.social · 19/11/2025
On the immune side 🧪: we found IFN-responsive T cells enriched in MDS that preferentially interact with iMSCs, hinting at a stromal-immune axis of bone marrow niche inflammation. An inflammatory feedback loop?
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Karin Prummel @kprummel.bsky.social · 19/11/2025
Key finding: we identified a novel population of “inflammatory mesenchymal stromal cells” (iMSCs) that appear in asymptomatic and already low-VAF CHIP and expand further in MDS, while healthy CXCL12+ adipogenic stromal cells decline in the bone marrow. 🧬🔬
100 1
Karin Prummel @kprummel.bsky.social · 19/11/2025
We studied human bone marrow samples from 84 donors (age-matched healthy controls, CHIP carriers, and early MDS patients) using single-cell RNA-seq, imaging, flow cytometry, and functional co-culture assays. 🧫 The scale of human stromal niche profiling is what makes this study special! 🦴🩸🧬🔬
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Karin Prummel @kprummel.bsky.social · 19/11/2025
🎯 Inflammation and niche remodelling are hallmarks in both CHIP to MDS, underscoring the role of the microenvironment in early myeloid disease. Targeting this stromal-immune remodelling could open new interception strategies.
100 1
Karin Prummel @kprummel.bsky.social · 19/11/2025
In co-culture experiments 🧫, we showed that healthy & CHIP HSPCs engaged with stromal cells to receive support 🩸🫂(e.g., CXCL12), but MDS HSPCs failed to do so. MDS blasts (!) even triggered an inflammatory program in stromal cells.
100 1
Karin Prummel @kprummel.bsky.social · 19/11/2025
On the immune side 🧪: we found IFN-responsive T cells enriched in MDS that preferentially interact with iMSCs, hinting at a stromal-immune axis of bone marrow niche inflammation. An inflammatory feedback loop?
100 1
Karin Prummel @kprummel.bsky.social · 19/11/2025
Key finding: we identified a novel population of “inflammatory mesenchymal stromal cells” (iMSCs) that appear in asymptomatic and already low-VAF CHIP and expand further in MDS, while healthy CXCL12+ adipogenic stromal cells decline in the bone marrow. 🧬🔬
100 1
Karin Prummel @kprummel.bsky.social · 19/11/2025
We studied human bone marrow samples from 84 donors (age-matched healthy controls, CHIP carriers, and early MDS patients) using single-cell RNA-seq, imaging, flow cytometry, and functional co-culture assays. 🧫 The scale of human stromal niche profiling is what makes this study special! 🦴🩸🧬🔬
100 1