Sasaki and colleagues generate human and macaque male germ cells up to meiotic onset, including prepachytene piRNA-expressing spermatogonia, from induced pluripotent stem cells. These cells self-organ...

Mayama and colleagues generate ACTH-responsive, cortisol- and androgen-producing human adrenocortical cells from induced pluripotent stem cells. This platform models prenatal functional zonation in vitro and in vivo, enabling mechanistic studies of human adrenal development and steroidogenesis and providing a foundation for future cell-based therapies for adrenal disorders.

Researchers led by Penn Vet’s Kotaro Sasaki and Michinori Mayama have developed an organoid system that faithfully mimics how the human adrenal gland develops and forms complex tissue structures, prov...

The adrenal cortex produces essential steroid hormones through a concentric zonal architecture, established by the centripetal trans-differentiation of subcapsular progenitors within a capsule-derived...