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koolchemistry.bsky.social

@koolchemistry.bsky.social
840 followers 1 following 32 posts
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koolchemistry.bsky.social @koolchemistry.bsky.social · 15/09/2026
I like this illustration I ran across. Imagining the prompt "make a model of DNA out of balloons"
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koolchemistry.bsky.social @koolchemistry.bsky.social · 01/09/2026
The 2'-OH group of RNA is surprisingly reactive, which is a good thing for labeling and probing. Our new paper with mechanistic studies to understand it has now been published - doi: 10.1002/chem.71285
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koolchemistry.bsky.social @koolchemistry.bsky.social · 31/08/2026
Thanks to the XXVI International Roundtable organizers for putting on a great meeting on nucleosides and nucleic acids last week in Barcelona --
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koolchemistry.bsky.social @koolchemistry.bsky.social · 21/11/2025
Excited that our paper on RiboLight (RL) dyes has been published - multicolor reactive dyes that are RNA-specific. They work great in gels and in live cells pubs.acs.org/doi/10.1021/jacs.5c14938
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koolchemistry.bsky.social @koolchemistry.bsky.social · 03/11/2025
We all know that DNA damage in our cells is dangerous - but how about in our food? Postdoc Jinwoo Shin's study shows that DNA in some foods is highly damaged by cooking and that it may be hazardous to us - pubs.acs.org/doi/10.1021/acs.jafc.5c08138
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koolchemistry.bsky.social @koolchemistry.bsky.social · 28/10/2025
Our study of pseudouridines in RNA was just published - it turns out that they stabilize RNA from cleavage by having much less nucleophilic 2'-OH groups: pubs.acs.org/doi/10.1021/acscentsci.5c01345
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koolchemistry.bsky.social @koolchemistry.bsky.social · 27/10/2025
I also had the privilege of speaking at the Samsung Science & Technology Foundation Global Research Symposium on Chemical Biology a few days ago in San Diego. It was packed with great research and discussions. A belated thanks to @Samsung
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koolchemistry.bsky.social @koolchemistry.bsky.social · 27/10/2025
I attended and spoke at the ACS Western Regional meeting this weekend - thanks to @ByronPurse for the invitation and for organizing a fun session on nucleoside and nucleic acids chemistry!
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koolchemistry.bsky.social @koolchemistry.bsky.social · 28/09/2025
Using a DNA-catalyst conjugate to place aryl groups at specific sequences in RNA - Congrats to Sumon Pratihar for leading the work! doi.org/10.1002/anie.202515681
doi.org
Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates
DNA oligonucleotides carrying amine nucleophilic catalysts are employed to deliver aryl groups to complementary sites in RNA under physiological conditions. The strategy can be used to sequence-speci...
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koolchemistry.bsky.social @koolchemistry.bsky.social · 05/09/2025
New and simple chemical modifications to poly(A) tails extend protein expression -- a really easy one-pot method Great work by Linglan Fang and Wenrui Zhong in our lab! doi.org/10.1021/jacs.5c11900
doi.org
Localized 2′-OH Acylation at Poly(A) Extends RNA Translation
The potential of coding RNAs as a general therapeutic modality is limited by their short intracellular lifetime. Here, we investigate the effects of localized post-transcriptional RNA modification on ...
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koolchemistry.bsky.social @koolchemistry.bsky.social · 26/03/2025
Spoke at Monday's ACS symposium in honor of Peter Dervan's birthday - it was a great time seeing Peter, Jackie, and the many alums who he trained
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koolchemistry.bsky.social @koolchemistry.bsky.social · 02/02/2025
Congratulations to Yixuan (Edward) Gao for publication of his paper on the first SMUG1 small molecule activator - it upregulates pyrimidine repair in cellular models. doi.org/10.1016/j.dnarep.2025.103809
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koolchemistry.bsky.social @koolchemistry.bsky.social · 24/12/2024
...and then I told it to give it the correct twist - not a particularly good result
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koolchemistry.bsky.social @koolchemistry.bsky.social · 24/12/2024
so I asked ChatGPT to make a cartoon of DNA - and it made it left handed...
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koolchemistry.bsky.social @koolchemistry.bsky.social · 19/12/2024
this one looks AI generated -not a helix, but looks helix-y
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koolchemistry.bsky.social @koolchemistry.bsky.social · 19/12/2024
Congrats to Edward Gao on the publication of his paper - an improved synthesis of damaged pyrimidines - doi: 10.1080/15257770.2024.2437038
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koolchemistry.bsky.social @koolchemistry.bsky.social · 27/11/2024
when a helix is not a helix
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koolchemistry.bsky.social @koolchemistry.bsky.social · 26/11/2024
DNA Publicity Art of the Day: ✘ left-hand twist ✅ dryer hose construction
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koolchemistry.bsky.social @koolchemistry.bsky.social · 25/11/2024
inaccurate DNA art of the day: gives new meaning to "DNA damage"
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koolchemistry.bsky.social @koolchemistry.bsky.social · 25/11/2024
Very small RNA-reactive reagents can map RNA in crowded spaces in the cell - congrats to Dr. Lu Xiao! doi: 10.1016/j.chembiol.2024.09.009
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