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Reposted by @kimboonekamp.bsky.social

Michael Boutros @michaelboutros.bsky.social · 02/05/2026

Our publication on 3D models for drug discovery is out! In the primer, we discuss the role of organoid models in drug discovery and development. Full article: www.sciencedirect.com/science/arti... @dkfz.bsky.social @uniheidelberg.bsky.social @hlsalliance.bsky.social @sfb1324.bsky.social

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Reposted by @kimboonekamp.bsky.social

Ulrich Schwarz @ulrichschwarz.bsky.social · 06/05/2026

Now out in Physical Review X: Cell Bulging and Extrusion in a Three-Dimensional Bubbly Vertex Model for Curved Epithelial Sheets Full article: doi.org/10.1103/x82g... With @omdrozdowski.bsky.social, Büşra Kocameşe-Tamgacı, @kimboonekamp.bsky.social and @michaelboutros.bsky.social. Here a 🧶 1/n

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kimboonekamp.bsky.social @kimboonekamp.bsky.social · 10/04/2025

(5/6) Moreover, we found that luminal pressure decreases and basal line tensions increase during budding, suggesting that budding has to be facilitated and stabilized by different mechanical processes.

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kimboonekamp.bsky.social @kimboonekamp.bsky.social · 10/04/2025

(4/6) Looking at different time points, we found that apico-basal tension differences increase after 48h, when budding occurs, as expected. However, we also found that afterwards they decrease again, suggesting a ratchet-like irreversibility of budding.

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kimboonekamp.bsky.social @kimboonekamp.bsky.social · 10/04/2025

(3/6) The method was verified with simulated data based on the bubbly vertex model.

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kimboonekamp.bsky.social @kimboonekamp.bsky.social · 10/04/2025

(2/6) Image stacks of mouse intestinal organoids were segmented using the statistics of point clouds to obtain a fully 3D reconstruction of the cells, including all surface normals. Then force balance was used to infer surface and line tensions.

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kimboonekamp.bsky.social @kimboonekamp.bsky.social · 10/04/2025

📝 New preprint! 📝 (1/6) Collaborative work between me and @omdrozdowski.bsky.social on 3D force inference for intestinal organoids is now on bioRxiv: www.biorxiv.org/content/10.1... From the labs of @ulrichschwarz.bsky.social and @michaelboutros.bsky.social .bsky.social with help from U. Engel.

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