The mycobacterial cell envelope plays both infectious and protective roles. Understanding its structure is crucial for unlocking the molecular basis underlying these functions. Studying glycans, the p...

Kiessling and colleagues developed EXT1−/− hPSCs to investigate the roles of HS polysaccharide in self-renewal and differentiation of hPSCs. The study revealed that HS is essential for early cell fate decisions of hPSCs toward mesoderm and endoderm lineages. HS deficiency allows for early ectoderm differentiation but impairs neuronal maturation.

Human lectins are critical carbohydrate-binding proteins that recognize diverse glycoconjugates from microorganisms and can play a key role in host-microbe interactions. Despite their importance in im...