Here’s a preprint from the Keating Lab: www.biorxiv.org/content/10.6.... Foster Birnbaum and Amy E. Keating demonstrate that sequence design models, such as ProteinMPNN, are limited because they were trained only on native sequences.
biorxiv.org
Keating Lab
@keatinglab.bsky.social
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MIT biology lab using computational and experimental methods to study protein structure, function, and interactions