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Kaspar Bachmann @kasparbachmann.bsky.social · 08/04/2026

Problem is twofold: LoA are around +/- 10%. ScvO2 of 55 then is not helpful. Trends do not point in the same direction. We showed this here: pubmed.ncbi.nlm.nih.gov/36511508/ And other studies: doi.org/10.1007/s00134… doi.org/10.1053/j.jvca�� Bottom line: when it counts, it is not helpful.

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Kaspar Bachmann @kasparbachmann.bsky.social · 03/12/2024

A PFO can act as a pressure valve in acute PE, but a PFO and DVT may also cause problems. I think depending on the thrombus load/anticoagulation strategy and specifics of the case, an IVCF merits a discussion. Video Reference: www.jacc.org/doi/10.1016/...

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Kaspar Bachmann @kasparbachmann.bsky.social · 01/12/2024

To add to the discussion, Gattinoni and colleagues published similar arguments in 2015, worth a read in my opinion. ccforum.biomedcentral.com/articles/10....

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Kaspar Bachmann @kasparbachmann.bsky.social · 29/11/2024

I agree, in a Vt range of 6-8 ml, the main component is dP. However, if you target low/very low dP (12-15) in a patient with poor compliance (very low tidal ventilation) and the increase in respiratory rate becomes relevant, I think. The figure is from the excellent paper you referenced (thanks).

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Kaspar Bachmann @kasparbachmann.bsky.social · 29/11/2024

The problem with decreasing driving pressure (or low Vt, which depending on the compliance is the same), is that RR has to go high to maintain gas exchange. This is especially pronounced in high deadspace states. Critical Care 2020, 24(Suppl 1):P090, (Page 35)

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Kaspar Bachmann @kasparbachmann.bsky.social · 22/11/2024

💯 the patient had severe mitral regurgitation. This lead to a postcapillary pulmonary hypertension with a high LVEDP. The prominent V-Wave in MR is sometimes challenging when introducing a PAC, as the signal stays „pulsatile“ and if not careful, can be misinterpreted. rdcu.be/d05K0

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Kaspar Bachmann @kasparbachmann.bsky.social · 18/11/2024

The common interpretation is that high stroke volume variation indicates fluid responsiveness. We show that SVV increases not only from preload dependency but also from RV afterload sensitivity. This explains why SVV often fails as a predictor of fluid responsiveness in RV dysfunction. 10/n

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Kaspar Bachmann @kasparbachmann.bsky.social · 18/11/2024

The relationship between coupling and ejection fraction: EF = 1/(1 + 1/coupling).When coupling = 2: EF ≈ 67% When coupling = 1: EF ≈ 50%. RV-PA coupling (Ees/Ea ratio) maintains a value near 2. This results in a EF of 60-67%, indicating optimal energy transfer from RV to circulation 7/n

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Kaspar Bachmann @kasparbachmann.bsky.social · 18/11/2024

When ECMO flow decreases by 1L/min, blood flow increases by 0.5L/min. Pulmonary artery pressure rises by 1.8mmHg. During hypoxic pulmonary vasoconstriction, contractility (Ees) increased by 1.4 mmHg/mL. With pulmonary embolism, the RV enhanced its contractility by 0.4 mmHg/mL. 6/n

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Kaspar Bachmann @kasparbachmann.bsky.social · 18/11/2024

The RV responds to increased afterload by enhancing contractility. Increases in #VenousReturn (i.e. preload) are met with dilation. This maintains the relationship between the RV and pulmonary elastance, i.e. mantains the RV-PA coupling. 4/n

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Kaspar Bachmann @kasparbachmann.bsky.social · 18/11/2024

As ECMO flow decreases, blood returns to the right heart, increasing preload. We wanted to analyze RV function (single beat method): We fitted a sine wave to the pressure curve to estimate maximum isovlumentric pressure, which can be used to estimate Ees (Elastance/Contractility of the RV). 3/n

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Kaspar Bachmann @kasparbachmann.bsky.social · 17/11/2024

Post a picture you took (no description) to bring some Zen into the timeline.

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Kaspar Bachmann @kasparbachmann.bsky.social · 16/11/2024

#BlueSky we just hit 18M. I hope the servers can handle the amount of traffic; Cool to see so many are transitioning and that journals are picking up on this too. Looking forward putting my #bluesky handle on the next publication we do… :) #MedSky

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Kaspar Bachmann @kasparbachmann.bsky.social · 16/11/2024

My old boss wrote an awesome publication on this: Low shunt (top left): SpO2 stays high despite poor cardiac output. High shunt (bottom right): SpO2 plummets unless cardiac output is very high. Figure reproduced from Takala, ICM 2007 using #MatLab link.springer.com/article/10.1...

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Kaspar Bachmann @kasparbachmann.bsky.social · 15/11/2024

The problem with the trial is that REBOA increased the time to definitive hemorrhage control (Table 2), so one might wonder if „speed“ were increased, there could still be a benefit.

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